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Rheumatoid Arthritis: Anticytokine Therapies on the Horizon

William J. Koopman, MD; and Larry W. Moreland, MD
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The University of Alabama at Birmingham; Birmingham, AL 35294 Grant Support: In part by National Institutes of Health grant R1AR44384A. Dr. Koopman is a principal investigator for studies sponsored by Sankyo, Inc., and has participated in clinical trials sponsored by Centocor, The Immune Response Corporation, and Immunex. Dr. Moreland is the Director of the Arthritis Clinical Intervention Program at The University of Alabama at Birmingham; has been a principal investigator for clinical trials sponsored by several pharmaceutical companies; and has been a consultant for Alexion Pharmaceuticals, Amgen, Biomatrix, Boehringer Ingelheim, Centocor, Connectics, Glaxo-Wellcome, Immunex, Knoll-BASF, Pharmacia/Upjohn, Schering-Plough Research Institute, Searle, SmithKline Beecham, TAP Holdings, and Wyeth. Requests for Reprints: William J. Koopman, MD, Department of Medicine, The University of Alabama at Birmingham, 402 Diabetes Education and Research Building, 1808 Seventh Avenue South, Birmingham, AL 35294-0012.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1998;128(3):231-233. doi:10.7326/0003-4819-128-3-199802010-00010
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The agents currently used to treat aggressive rheumatoid arthritis, the so-called disease-modifying antirheumatic drugs, were generally not developed for that purpose. At best, they reduce the destructive component of the disease modestly and inconsistently.

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