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Update in Endocrinology

Janet A. Schlechte, MD; and Robert Kreisberg, MD
[+] Article and Author Information

From the University of Iowa, Iowa City, Iowa; and Baptist Health System, Birmingham, Alabama. Requests for Reprints: Janet Schlechte, MD, Clinical Research Center, Room 157, MRF, University of Iowa, Iowa City, IA 52242. Current Author Addresses: Dr. Schlechte: Clinical Research Center, Room 157, MRF, University of Iowa, Iowa City, IA 52242.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1998;128(5):378-385. doi:10.7326/0003-4819-128-5-199803010-00007
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Advances in endocrinology in 1996 occurred in many areas. First, another drug was added to the growing list of agents used to treat type 2 diabetes mellitus. Second, an additional agent was found to be effective in decreasing low-density lipoprotein (LDL) cholesterol and triglyceride levels and thus may provide more effective prevention of atherosclerotic vascular disease. Third, the bisphosphonates, especially the oral drug alendronate, were shown to benefit patients with a broad array of bone diseases. In addition, 1996 was a year of studies that contributed to the debate over the use of human growth hormone. Finally, estrogen therapies were shown not only to delay bone loss in postmenopausal women but also to actually increase bone mineral density.

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Grahic Jump Location
Figure 1.
Therapeutic approach to type 2 diabetes mellitus.1c

* Typical goal would be a hemoglobin A level of 0.07 or less.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Comparison of effects of four HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors.
Grahic Jump Location

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Type 2 diabetes mellitus and fracture risk. Metabolism 2014;63(12):1480-1490.
Acromegaly and bone disease. Curr Opin Endocrinol Diabetes Obes 2014;21(6):476-82.
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