The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Histologic and Cytokine Response to Immunosuppression in Giant-Cell Myocarditis

Nat T. Levy, MD; Lyle J. Olson, MD; Cornelia Weyand, MD, PhD; Alexander Brack, MD; Henry D. Tazelaar, MD; William D. Edwards, MD; and Stephen C. Hammill, MD
[+] Article, Author, and Disclosure Information

From the Mayo Clinic, Rochester, Minnesota. Requests for Reprints: Lyle J. Olson, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. Current Author Addresses: Dr. Levy: 8360 Delmare #2N, St. Louis, MO 63124.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1998;128(8):648-650. doi:10.7326/0003-4819-128-8-199804150-00007
Text Size: A A A

Giant-cell myocarditis is characterized by heart block, ventricular arrhythmia, congestive heart failure, and a high mortality rate [13]. A previous study [4] suggested that myocardial inflammation is mediated by T cells and giant cells. We report on two patients with giant-cell myocarditis, one of whom responded favorably to cytolytic therapy with muromonab-CD3. Cytokine analysis, immunophenotyping, and T-cell receptor α-chain quantitation were performed to characterize the immunologic features of giant-cell myocarditis.

First Page Preview

View Large
First page PDF preview


Grahic Jump Location
Figure 1.
Giant-cell myocarditis.Top.Bottom.

Active giant-cell myocarditis. Initial pretreatment biopsy showed several giant cells and a mixed lymphocyte-eosinophilic infiltrate (hematoxylin and eosin; original magnification, x250). Healing giant-cell myocarditis. Biopsy after therapy showed interstitial fibrosis with residual mononuclear cells but no giant cells or myocyte necrosis (hematoxylin and eosin; original magnification, x250).

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.