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Antilymphocyte Antibodies, Renal Transplantation, and Meta-Analysis

Andrew S. Levey, MD; Christopher H. Schmid, PhD; and Joseph Lau, MD
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New England Medical Center; Boston, MA 02111 Requests for Reprints: Andrew S. Levey, MD, New England Medical Center, Box 784, 750 Washington Street, Boston, MA 02111. Grant Support: In part by Agency for Health Care Policy and Research grants RO1 HS 07782 and RO1 HS 08532.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1998;128(10):863-865. doi:10.7326/0003-4819-128-10-199805150-00011
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Antibodies directed against human lymphocytes are among the most potent immunosuppressive agents available for organ transplantation [16]. These biological preparations, referred to here as antilymphocyte antibodies, vary in the type of cell (lymphocyte, lymphoblast, thymocyte) used to induce the antibody response and the host (horse, rabbit, mouse-human hybridoma) in which the response is induced. When used to treat acute rejection, they improve graft survival. When used as induction therapy immediately after transplantation, they reduce the risk for acute rejection, but clinical trials have not shown them to have a beneficial effect on graft survival, in part because these trials did not have adequate power to assess this outcome.

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