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Resisting Resistance: Maximizing the Durability of Antiretroviral Therapy

Jon H. Condra, PhD
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Merck Research Laboratories; West Point, PA 19486 Requests for Reprints: Jon H. Condra, PhD, Department of Antiviral Research, Merck & Co., Inc., WP26-339, West Point, PA 19486.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1998;128(11):951-954. doi:10.7326/0003-4819-128-11-199806010-00017
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In the past 3 years, a veritable explosion of data has yielded new insight into the biology of HIV infection and the pathogenesis of AIDS. It is now well known that HIV infection, even during its long asymptomatic phase, is characterized by high rates of viral replication and destruction of CD4+ cells, which ultimately lead to immune deficiency, AIDS-defining illnesses, and death. Consequently, inhibition of viral replication has assumed primary importance in the control of AIDS.

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