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Low-Molecular-Weight Heparins in the Treatment of Venous Thromboembolism

Maria M.W. Koopman, MD; and Harry R. Buller, MD
[+] Article and Author Information

University of Amsterdam; Amsterdam, the Netherlands Grant Support: Dr. Buller is an Established Investigator of the Dutch Heart Foundation. Requests for Reprints: Maria M.W. Koopman, Academic Medical Center, University of Amsterdam, Center for Haemostasis, Thrombosis and Atherosclerosis and Inflammation Research, F4-133, Postbox 22700, 1100 DE Amsterdam, the Netherlands. Current Author Addresses: Drs. Koopman and Buller: Academic Medical Center, University of Amsterdam, Center for Haemostasis, Thrombosis and Atherosclerosis and Inflammation Research, F4-133, Postbox 22700, 1100 DE Amsterdam, the Netherlands.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1998;128(12_Part_1):1037-1039. doi:10.7326/0003-4819-128-12_Part_1-199806150-00016
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For many decades, the conventional wisdom has been that patients with a diagnosis of acute venous thromboembolic disease confirmed by objective techniques should receive an initial continuous intravenous course of unfractionated heparin for at least 5 days to prevent early and late recurrences [12]. Oral anticoagulant therapy can be started simultaneously and should be continued for at least 3 months [3]. Because the pharmacokinetic response of unfractionated heparin is unpredictable, daily laboratory monitoring and dose adjustments are required; therefore, hospital admission for treatment of acute thromboembolic disease is usually unavoidable [4].

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