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Linking Antimicrobial Use to Nosocomial Infections: The Role of a Combined Laboratory-Epidemiology Approach

L. Clifford McDonald, MD; and William R. Jarvis, MD
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Centers for Disease Control and Prevention; Atlanta, GA 30333 Requests for Reprints: William R. Jarvis, MD, Hospital Infections Program, Centers for Disease Control and Prevention, 1600 Clifton Road, MS E69, Atlanta, GA 30333; e-mail, wrj1@cdc.gov. Current Author Addresses: Drs. McDonald and Jarvis: Hospital Infections Program, Centers for Disease Control and Prevention, 1600 Clifton Road, MS E69, Atlanta, GA 30333.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1998;129(3):245-247. doi:10.7326/0003-4819-129-3-199808010-00014
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Nosocomial infections are an important cause of increased morbidity, mortality, and health care costs worldwide. Conservative estimates for 1992 were that nosocomial infections increased the annual cost of health care in the United States by more than $4.5 billion [1] and contributed to almost 80 000 deaths. Nosocomial infections may be one of the five leading causes of death in the United States, and we must make their prevention a public health priority [23].

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