0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Genetics of Familial Mediterranean Fever and Its Implications

George E. Ehrlich, MD
[+] Article and Author Information

Philadelphia, PA 19106 Requests for Reprints: George E. Ehrlich, MD, One Independence Place (1101), 241 South Sixth Street, Philadelphia, PA 19106-3731.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1998;129(7):581-582. doi:10.7326/0003-4819-129-7-199810010-00014
Text Size: A A A

In 1945, Dr. Sheppard Siegal, an allergist at Mount Sinai Hospital in New York, reported in Annals five cases of “recurrent paroxysms of severe abdominal pain with fever … as high as 105 °F,” all in men and all starting early in life. He named the syndrome benign paroxysmal peritonitis [1]. The peritoneal signs were so severe that “emergency operation [had] been repeatedly urged.” Pleuritic chest pain often accompanied the attacks. At least one of the patients had “urticarial” lesions near the ankle, and another had intermittent joint pains, usually monoarticular. As an allergist, Siegal approached these cases from his own vantage point, and the history of this condition is replete with references to potential allergens and allergic relatives. Unfortunately, except for noting that all of the patients were white men, he provided no other ethnic background data. Although an occasional similar case was found in previous published series, including some in which such manifestations were interpreted as “Henoch” purpura (from which Siegal clearly differentiated the condition), this landmark article was essentially the first to describe the clinical presentation of what is now known as familial Mediterranean fever.

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)