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Update in Allergy and Immunology

Mark T. O'Hollaren, MD
[+] Article, Author, and Disclosure Information

1998-99 Series; John Roberts, MD, Editor From Oregon Health Sciences University, Portland, Oregon. Requests for Reprints: Mark T. O'Hollaren, MD, Department of Medicine, Oregon Health Sciences University, 0P30, 3181 SW Sam Jackson Park, Portland, OR 97201. Current Author Addresses: Dr. O'Hollaren: Allergy Clinic, 511 SW 10th Avenue, Suite 1301, Portland, OR 97205.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1998;129(12):1036-1043. doi:10.7326/0003-4819-129-12-199812150-00008
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We are just beginning to understand the associations between the immune system's physiology and clinical symptoms. This knowledge is facilitating the development of new therapies for allergic disorders. We begin with a review of new guidelines for the asthma therapy that, in part, stem from our new understanding of immune pathophysiology. We then review several advances in asthma therapy related to medication timing, longer-acting inhaled β2 agonists, and leukotriene antagonists and summarize current thinking on mortality related to asthma. We discuss the immune response in allergic rhinitis, the role of inhalant allergens in allergic rhinitis, and associations between asthma and allergic rhinitis. Finally, we address latex allergy, a growing clinical problem for health care workers.

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