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Effect of Inhaled Nitric Oxide on Gas Exchange in Patients with Congestive Heart Failure: A Randomized, Controlled Trial

Akihiro Matsumoto, MD; Shin-ichi Momomura, MD; Seiryo Sugiura, MD; Hideo Fujita, MD; Teruhiko Aoyagi, MD; Masataka Sata, MD; Masao Omata, MD; and Yasunobu Hirata, MD
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From the University of Tokyo, Tokyo, Japan.


Ann Intern Med. 1999;130(1):40-44. doi:10.7326/0003-4819-130-1-199901050-00008
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Background: Conventional vasodilators increase ventilation-perfusion mismatch and do not improve gas exchange even though they reduce pulmonary hypertension. However, the effects of nitric oxide inhalation on ventilatory and gas exchange values in patients with congestive heart failure are not known.

Objective: To investigate the effect of nitric oxide inhalation on gas exchange in patients with congestive heart failure.

Design: Randomized, controlled trial.

Setting: University hospital.

Patients: 16 patients with congestive heart failure (New York Heart Association class II or III).

Interventions: Patients inhaled nitric oxide gas at graded concentrations (n = 8) or were given intravenous isosorbide dinitrate, 2.5 mg (n = 8).

Measurements: Hemodynamic and ventilatory variables and blood gases were measured 5 minutes after inhalation of different doses of nitric oxide and 10 minutes after administration of isosorbide dinitrate.

Results: Nitric oxide inhalation reduced the mean pulmonary arterial pressure in a dose-dependent manner without altering the mean arterial pressure or cardiac output. At a dose of 40 parts per million, nitric oxide inhalation increased PaO2 (change from baseline, 12.0 mm Hg [95% CI, 2.3 to 21.7 mm Hg]; P = 0.014) and decreased the alveolar-arterial difference in partial pressure of oxygen (change, −8.6 mm Hg [CI, −16.8 to −0.4 mm Hg]; P = 0.038) and the ventilatory equivalent for carbon dioxide output (change, −6.7 [CI, −10.3 to −3.1]; P < 0.001). Although isosorbide dinitrate similarly decreased pulmonary arterial pressure, it did not alter gas exchange or ventilatory variables.

Conclusions: Because nitric oxide inhalation improved gas exchange, it may be used as a supportive therapy when other conventional vasodilators worsen gas exchange.

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