The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Mycophenolate Mofetil for the Treatment of Takayasu Arteritis: Report of Three Cases

Erica Daina, MD; Arrigo Schieppati, MD; and Giuseppe Remuzzi, MD
[+] Article, Author, and Disclosure Information

From Mario Negri Institute and Ospedali Riuniti di Bergamo, Bergamo, Italy.

Ann Intern Med. 1999;130(5):422-426. doi:10.7326/0003-4819-130-5-199903020-00013
Text Size: A A A

Background: Takayasu arteritis is a rare form of chronic inflammatory disease of the large arterial vessels. Some patients do not respond to steroids or immunosuppressant drugs.

Objective: To evaluate the effect of mycophenolate mofetil in patients with severe Takayasu arteritis.

Design: Case series.

Setting: Clinical Research Center for Rare Diseases in Bergamo, Italy.

Patients: Three patients with Takayasu arteritis.

Intervention: Mycophenolate mofetil (2 g/d) given orally in two divided doses.

Measurements: Clinical evaluation and assessment of leukocyte counts were done weekly. Vascular lesions were assessed by using Doppler ultrasonography.

Results: All patients showed clinical benefit, and two resumed work after months of inactivity. Patients were also able to taper and discontinue steroid use. Mycophenolate mofetil was well tolerated, and no signs of toxicity were observed.

Conclusions: Mycophenolate mofetil may be an alternative to steroids and cytotoxic agents in patients with Takayasu arteritis. Before results of controlled trials become available, mycophenolate mofetil should be considered only for patients who do not improve or stabilize with conventional therapy.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.