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Critical Limb Ischemia: Nothing To Give at the Office?

Robert M. Schainfeld, DO; and Jeffrey M. Isner, MD
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St. Elizabeth's Medical Center; Boston, MA 02135 (Schainfeld) St. Elizabeth's Medical Center; Boston, MA 02135 (Isner)

Ann Intern Med. 1999;130(5):442-444. doi:10.7326/0003-4819-130-5-199903020-00017
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Prognosis for patients with critical leg ischemia is often poor, and no pharmacotherapy has been effective. In this issue, the ICAI Study Group reports that prostaglandin E1 used to treat this condition had initial benefits that disappeared with time. Another potential medical approach to critical leg ischemia that has shown early promise is the use of gene transfer to repair the vascular system.

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