The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study

Bruce F. Culleton, MD; Martin G. Larson, ScD; William B. Kannel, MD; and Daniel Levy, MD
[+] Article, Author, and Disclosure Information

From the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts; and Boston University School of Medicine, Boston, Massachusetts.

Grant Support: The Framingham Heart Study is supported by National Institutes of Health/National Heart, Lung, and Blood Institute contract N01-HC-38038. This investigation was supported in part by a research grant from Merck and Co., Inc. Dr. Culleton is a recipient of the 1997-1999 Kidney Foundation of Canada Fellowship.

Requests for Reprints: Daniel Levy, MD, Framingham Heart Study, 5 Thurber Street, Framingham, MA 01702; e-mail, Dan@fram.nhlbi.nih.gov.

Current Author Addresses: Dr. Culleton: Division of Nephrology, University of Calgary, Foothills Hospital, Room C-210, 1403 29th Street, Calgary, Alberta T2N 2T9, Canada.

Drs. Larson, Kannel, and Levy: Framingham Heart Study, 5 Thurber Street, Framingham, MA 01702.

Ann Intern Med. 1999;131(1):7-13. doi:10.7326/0003-4819-131-1-199907060-00003
Text Size: A A A

The association of serum uric acid with cardiovascular disease has been appreciated for nearly half a century (1). Several prospective studies have shown an association between baseline hyperuricemia and incident coronary heart disease, cardiovascular disease, and death (210). Despite the strength of these associations, uric acid has not been established as a causal risk factor for cardiovascular disease. Instead, uric acid seems inextricably linked to hypertension, dyslipidemia, and disordered glucose metabolism, which play a causal role in the pathogenesis of cardiovascular disease. As such, uric acid may be merely a marker of risk for cardiovascular disease.

First Page Preview

View Large
First page PDF preview


Grahic Jump Location
Mean serum uric acid level by sex and 5-year age group.

Solid line represents men; dashed line represents women; squares represent values at midpoint of 5-year age group; and vertical bars represent 95% CIs.

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.