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Risk Factors for Cardiovascular Disease: One Down, Many More To Evaluate

Viola Vaccarino, MD, PhD; and Harlan M. Krumholz, MD
[+] Article and Author Information

Yale University School of Medicine; New Haven, CT 06520 (Vaccarino) Yale University School of Medicine; New Haven, CT 06520 (Krumholz)


Grant Support: Dr. Krumholz is a Paul Beeson Faculty Scholar.

Requests for Reprints: Harlan M. Krumholz, MD, Yale University School of Medicine, 333 Cedar Street, IE-61 SHM, New Haven, CT 06520.

Current Author Addresses: Dr. Krumholz: Yale University School of Medicine, 333 Cedar Street, IE-61 SHM, New Haven, CT 06520.

Dr. Vaccarino: Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520.


Ann Intern Med. 1999;131(1):62-63. doi:10.7326/0003-4819-131-1-199907060-00012
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Almost 50 years ago, investigators observed the association between uric acid and cardiovascular events. Subsequently, many epidemiologic studies have sought to clarify the role of this risk factor. In addition, laboratory studies have attempted to identify the mechanism by which an elevated uric acid level causes an increased risk for cardiovascular disease. Despite these efforts, the role of uric acid as a risk factor was never fully resolved.

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