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Antibiotic Treatment of Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue: An Uncontrolled Trial

Gideon Steinbach, MD, PhD; Richard Ford, MD, PhD; Gary Glober, MD; Dory Sample, RN; Frederick B. Hagemeister, MD; Patrick M. Lynch, MD, JD; Peter W. McLaughlin, MD; Maria A. Rodriguez, MD; Jorge E. Romaguera, MD; Andreas H. Sarris, MD, PhD; Anas Younes, MD; Rajyalakshmi Luthra, PhD; John T. Manning, MD; Constance M. Johnson, BSN; Sandeep Lahoti, MD; Yu Shen, PhD; Jeffrey E. Lee, MD; Rodger J. Winn, MD; Robert M. Genta, MD; David Y. Graham, MD; and Fernando F. Cabanillas, MD
[+] Article, Author, and Disclosure Information

From The University of Texas, M.D. Anderson Cancer Center, and Houston Veterans Affairs Medical Center, Houston, Texas.

Grant Support: By National Cancer Institute grant RO1 CA67540-0 2 and Cancer Center Support grant CA-16672.

Requests for Reprints: Gideon Steinbach, MD, PhD, Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas, M.D. Anderson Cancer Center, Box 78, 1515 Holcombe Boulevard, Houston, TX 77030; e-mail, gsteinb@aol.com.

Current Author Addresses: Drs. Steinbach, Ford, Glober, Hagemeister, Lynch, McLaughlin, Rodriguez, Romaguera, Sarris, Younes, Luthra, Manning, Lahoti, Shen, Lee, Winn, and Cabanillas, Ms. Sample, and Ms. Johnson: The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030.

Drs. Genta and Graham: Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030.

Ann Intern Med. 1999;131(2):88-95. doi:10.7326/0003-4819-131-2-199907200-00003
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Gastric low-grade B-cell lymphoma is related to Helicobacter pylori infection according to histopathologic, epidemiologic, and clinical characteristics. Although normal gastric mucosa does not contain organized lymphoid tissue, lymphoid follicles develop with H. pylori infection (1) and with autoimmune diseases, such as the Sjögren syndrome (2). Low-grade B-cell lymphoma has been postulated to arise within this mucosa-associated lymphoid tissue (MALT) and is often called low-grade MALT lymphoma (34).

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