The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Effects of Metformin in Patients with Poorly Controlled, Insulin-Treated Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial

Larissa Avilés-Santa, MD; Joyce Sinding, MSN, RN; and Philip Raskin, MD
[+] Article, Author, and Disclosure Information

From University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

Acknowledgments: The authors are indebted to Susan Cercone, RD, MSD, CDE, for her assistance in obtaining and evaluating diet histories and Dr. William Frawley, biostatistician at the University of Texas Southwestern Medical Center, whose comments were invaluable in the preparation of the manuscript.

Grant Support: In part by a grant from Bristol-Myers Squibb (Protocol 7034-BS).

Requests for Reprints: Philip Raskin, MD, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard G5.238, Dallas, TX 75235-8858.

Current Author Addresses: Drs.Avilés-Santa and Ms. Sinding: University of Texas SouthwesternMedical Center, 5323 Harry Hines Boulevard G4.100, Dallas, TX 75235-8858.

Dr. Raskin: University of Texas SouthwesternM edical Center, 5323 Harry Hines Boulevard G5.238, Dallas, TX 75235-8858.

Ann Intern Med. 1999;131(3):182-188. doi:10.7326/0003-4819-131-3-199908030-00004
Text Size: A A A

Type 2 diabetes mellitus is more prevalent among persons and populations in which obesity or a family history of the disease is present. Modification of dietary habits and subsequent weight loss (important steps in the management of both obesity and diabetes) improve glycemic control. However, glycemic goals are usually not achieved by dietary restriction alone, andpharmacologic intervention is often necessary. Until 1995, sulfonylurea compounds were the only oral antihyperglycemic agents available in the United States for initial drug therapy for type 2 diabetes (13). These agents have a high rate of secondary failure (13), however, and the addition of other oral agents or insulin is often necessary.

First Page Preview

View Large
First page PDF preview


Grahic Jump Location
Figure 1.
Change in hemoglobin A1c level from baseline to 24 weeks.P

Error bars represent the standard deviation. * < 0.001 compared with baseline.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Change in daily insulin dosage from baseline to 24 weeks.P

Error bars represent SDs. * < 0.001 compared with baseline.

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.