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Cardiac and Arterial Target Organ Damage in Adults with Elevated Ambulatory and Normal Office Blood Pressure

Jennifer E. Liu, MD; Mary J. Roman, MD; Riccardo Pini, MD; Joseph E. Schwartz, PhD; Thomas G. Pickering, MD; and Richard B. Devereux, MD
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From The New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York; and the University of Florence, Florence, Italy.


Grant Support: In part by grants HL 18323, HL 30606 and HL 47540 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland.

Requests for Reprints: Richard B. Devereux, MD, Division of Cardiology, Box 222, The New York Presbyterian Hospital-Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021; e-mail, rbdevere@mail.med.cornell.edu.

Current Author Addresses: Drs. Liu, Roman, Schwartz, and Pickering: The New York Presbyterian Hospital-Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021.

Dr. Pini: Division of Gerontology and Geriatrics, University of Florence, via della Oblate 4, Florence 50141, Italy.

Dr. Devereux: Division of Cardiology, Box 222, The New York Presbyterian Hospital-Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021.


Ann Intern Med. 1999;131(8):564-572. doi:10.7326/0003-4819-131-8-199910190-00003
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Epidemiologic studies have established that hypertension, detected by clinical blood pressure measurement, is a major contributor to cardiovascular mortality and morbidity (12). Although this relation is highly significant in large populations, only a weak relation exists between blood pressure and likelihood of cardiovascular complications (3). In addition, the factors predisposing normotensive patients to cardiovascular complications have only been partially elucidated. One possible explanation is that office blood pressure readings, on which the existing epidemiologic data are based, may not consistently reflect the overall blood pressure load imposed on the heart and arterial tree because of the wide variations in blood pressure that occur during normal activity.

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Summary for Patients

Organ Damage in Different Types of High Blood Pressure

The summary below is from the full report titled “Cardiac and Arterial Target Organ Damage in Adults with Elevated Ambulatory and Normal Office Blood Pressure.” It is in the 19 October 1999 issue of Annals of Internal Medicine (volume 131, pages 564-572). The authors are J.E. Liu, M.J. Roman, R. Pini, J.E. Schwartz, T.G. Pickering, and R.B. Devereux.

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