0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Chlorhexidine Compared with Povidone-Iodine as Skin Preparation before Blood Culture: A Randomized, Controlled Trial

Olivier Mimoz, MD, PhD; Amal Karim, PharmD; Alain Mercat, MD; Marie Cosseron, MD; Bruno Falissard, MD, PhD; Fabrice Parker, MD, PhD; Christian Richard, MD; Kamran Samii, MD; and Patrice Nordmann, MD, PhD
[+] Article and Author Information

From the Université Paris XI, Hôpital de Bicêtre, and Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre Cedex, France.


Acknowledgments: The authors thank the patients, physicians, and nurses of Hôpital Bicêtre for their cooperation and assistance.

Grant Support: By Zeneca Pharma and University Paris XI (UPRES, JE 2227).

Requests for Reprints: Olivier Mimoz, MD, PhD, Service d'Anesthésie-Réanimation, Hôpital Paul Brousse, 10 avenue Paul-Vaillant Couturier, 94809 Villejuif Cedex, France.

Current Author Addresses: Dr. Mimoz: Service d'Anesthésie-Réanimation, Hôpital Paul Brousse, 10 avenue Paul-Vaillant Couturier, 94809 Villejuif Cedex, France.

Drs. Karim, Cosseron, and Nordmann: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre Cedex, France.

Drs. Mercat and Richard: Service de Réanimation Médicale, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre Cedex, France.

Dr. Falissard: INSERM-U472, Hôpital Paul Brousse, 16 avenue Paul-Vaillant Couturier, 94807 Villejuif Cedex, France.

Dr. Parker: Service de Neuro-Chirurgie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre Cedex, France.

Dr. Samii: Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre Cedex, France.


Ann Intern Med. 1999;131(11):834-837. doi:10.7326/0003-4819-131-11-199912070-00006
Text Size: A A A

Background: Chlorhexidine is better than povidone-iodine for care of catheter sites, but it is not known whether chlorhexidine is superior in reducing blood culture contamination.

Objective: To determine whether alcoholic chlorhexidine is a more effective skin antiseptic for collection of blood cultures than aqueous povidone-iodine.

Design: Randomized, controlled trial.

Setting: Three adult intensive care units in a French university hospital.

Patients: 403 adults who had at least one blood culture drawn through a peripheral vein.

Interventions: Patients were randomly assigned to receive skin preparation with an aqueous solution of 10% povidone-iodine or an alcoholic solution of 0.5% chlorhexidine before phlebotomy.

Measurements: Contamination rates of blood cultures.

Results: Of 2041 blood cultures collected in 403 patients, 124 yielded pathogens. Chlorhexidine reduced the incidence of blood culture contamination more than povidone-iodine (14 of 1019 cultures [1.4%] compared with 34 of 1022 cultures [3.3%]; odds ratio, 0.40 [95% CI, 0.21 to 0.75]; P = 0.004).

Conclusion: Skin preparation with alcoholic chlorhexidine is more efficacious than skin preparation with aqueous povidone-iodine in reducing contamination of blood cultures.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Comparison of Two Antiseptic Solutions To Disinfect the Skin for Blood Cultures

The summary below is from the full report titled “Chlorhexidine Compared with Povidone-Iodine as Skin Preparation before Blood Culture. A Randomized, Controlled Trial.” It is in the 7 December 1999 issue of Annals of Internal Medicine (volume 131, pages 834-837). The authors are O. Mimoz, A. Karim, A. Mercat, M. Cosseron, B. Falissard, F. Parker, C. Richard, K. Samii, and P. Nordmann.

Read More...

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)