After taking rosiglitazone for 1 week, the patient had developed abdominal pain, nausea, loss of appetite, and fatigue. His symptoms worsened over time, and he stopped taking the medication after 3 weeks. Five days later, he was admitted to the hospital with abdominal pain and shortness of breath, and rapidly became comatose. He also developed an abnormally slow heart rate and low blood pressure. In addition to diabetes, his previous medical problems included high blood pressure, coronary artery disease, and an abnormal heart rhythm (atrial fibrillation). Blood tests in the hospital for liver damage were extremely abnormal; they had been normal before the patient began rosiglitazone.