After taking rosiglitazone for 8 days, the patient had developed nausea, vomiting, decreased appetite, and abdominal pain, but he continued taking the drug. One week later, he was hospitalized with worsening symptoms. In addition to diabetes, the patient had lung disease and a history of alcoholism in the distant past. Eight months before this hospital admission, the patient had started taking a related diabetes drug, troglitazone, but stopped it because of abdominal pain. His liver function had been normal at that time. He had also taken repaglinide, a diabetes medication from a different class of drugs, starting 7 weeks before hospitalization but stopped it after 5 weeks because of nausea and dizziness. He then started rosiglitazone. The patient's other medications were acetaminophen (Tylenol) and drugs for his lung disease.