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Nonsedating Antihistamines Should Be Preferred over Sedating Antihistamines in Patients Who Drive

Sean Hennessy, PharmD, MSCE; and Brian L. Strom, MD, MPH
[+] Article, Author, and Disclosure Information

University of Pennsylvania School of Medicine; Philadelphia, PA 19104-6021 (Hennessy) University of Pennsylvania School of Medicine; Philadelphia, PA 19104-6021 (Strom)

Grant Support: By the National Institute on Aging (R01 AG14601).

Requests To Purchase Bulk Reprints (minimum, 100 copies): Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org.

Current Author Addresses: Dr. Hennessy: University of Pennsylvania, 803 Blockley Hall, Philadelphia, PA 19104-6021.

Dr. Strom: University of Pennsylvania, 823 Blockley Hall, Philadelphia, PA 19104-6021.

Ann Intern Med. 2000;132(5):405-407. doi:10.7326/0003-4819-132-5-200003070-00011
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Allergic rhinitis is very common, affecting approximately 16% of the U.S. population (1). Although therapy with intranasal corticosteroids and intranasal cromolyn has gained acceptance in recent years (2), antihistamines (H1-receptor antagonists) remain the first-line treatment. The possible differential effects of sedating compared with nonsedating antihistamines on driving performance and the risk for motor vehicle crashes represent an important consideration in choosing between the two categories of agents in patients who drive.

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