0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Histologic Improvement of Fibrosis in Patients with Hepatitis C Who Have Sustained Response to Interferon Therapy

Yasushi Shiratori, MD; Fumio Imazeki, MD; Mitsuhiko Moriyama, MD; Michitami Yano, MD; Yasuyuki Arakawa, MD; Osamu Yokosuka, MD; Tetsuo Kuroki, MD; Shuhei Nishiguchi, MD; Michio Sata, MD; Gotarou Yamada, MD; Shigetoshi Fujiyama, MD; Haruhiko Yoshida, MD; and Masao Omata, MD
[+] Article and Author Information

From University of Tokyo and Nihon University School of Medicine, Tokyo; Chiba University School of Medicine, Chiba; National Nagasaki Central Hospital, Nagasaki; Osaka City University School of Medicine, Osaka; Kurume University School of Medicine, Fukuoka; Kawasaki University School of Medicine, Okayama; and Kumamoto University School of Medicine, Kumamoto, Japan.


† Deceased.

Grant Support: By the Ministry of Health and Welfare of Japan as one of the Comprehensive 10-Year Strategy for Cancer Control Projects.

Requests for Single Reprints: Yasushi Shiratori, MD, Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org.

Current Author Addresses: Drs. Shiratori, Yoshida, and Omata: Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Drs. Imazeki and Yokosuka: First Department of Internal Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan.

Drs. Moriyama and Arakawa: Third Department of Internal Medicine, Nihon University, 30-1 Oyaguchi, Itabashi-ku, Tokyo 173-8610, Japan.

Dr. Yano: Department of Clinical Research, National Nagasaki Chuo Hospital, 2-1001-1, Kuhara, Ohmura, Nagasaki 856-0835, Japan.

Dr. Nishiguchi: Third Department of Internal Medicine, Osaka City University, 1-5-7 Asahi-cho, Abeno-ku, Osaka 545-8586, Japan.

Dr. Sata: Second Department of Internal Medicine, Kurume University, 67 Asahi-cho, Kurume, Fukuoka 830-0011, Japan.

Dr. Yamada: Liver Unit, Kawasaki Medical School, 2-1-80 Nakayama-shita, Okayama, Okayama 700-0821, Japan.

Dr. Fujiyama: Third Department of Internal Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-8556, Japan.

Author Contributions: Conception and design: Y. Shiratori, F. Imazeki, M. Moriyama, M. Yano, Y. Arakawa, O. Yokosuka, T. Kuroki, S. Nishiguchi, M. Sata, G. Yamada, S. Fujiyama, H. Yoshida, M. Omata.

Analysis and interpretation of the data: Y. Shiratori, H. Yoshida, M. Omata.

Drafting of the article: Y. Shiratori.

Critical revision of the article for important intellectual content: Y. Shiratori, F. Imazeki, M. Moriyama, M. Yano, Y. Arakawa, O. Yokosuka, T. Kuroki, S. Nishiguchi, M. Sata, G. Yamada, S. Fujiyama, H. Yoshida, M. Omata.

Final approval of the article: Y. Shiratori, F. Imazeki, M. Moriyama, M. Yano, Y. Arakawa, O. Yokosuka, T. Kuroki, S. Nishiguchi, M. Sata, G. Yamada, S. Fujiyama, H. Yoshida, M. Omata.

Provision of study materials or patients: Y. Shiratori, F. Imazeki, M. Moriyama, M. Yano, Y. Arakawa, O. Yokosuka, T. Kuroki, S. Nishiguchi, M. Sata, G. Yamada, S. Fujiyama, H. Yoshida, M. Omata.

Statistical expertise: Y. Shiratori, H. Yoshida, M. Omata.

Obtaining of funding: M. Omata.

Administrative, technical, or logistic support: Y. Shiratori, M. Omata.

Collection and assembly of data: Y. Shiratori, F. Imazeki, M. Moriyama, M. Yano, Y. Arakawa, O. Yokosuka, T. Kuroki, S. Nichiguchi, M. Sata, G. Yamada, S. Fujiyama, H. Yoshida, M. Omata.


Ann Intern Med. 2000;132(7):517-524. doi:10.7326/0003-4819-132-7-200004040-00002
Text Size: A A A

Chronic hepatitis C is a common disease that may progress to cirrhosis (14) and hepatocellular carcinoma (58). In some patients, treatment with interferon, alone or in combination with ribavirin, leads to sustained eradication of virus (9). Recent follow-up studies revealed that patients who were negative for hepatitis C virus (HCV) RNA 6 months after treatment remained in remission and had normal liver function and improved histologic features, suggesting possible cure (1012). Although hepatic inflammation improves histologically in such patients (1317), it remains uncertain whether hepatic fibrosis can also regress.

First Page Preview

View Large
/>
First page PDF preview

Figures

Grahic Jump Location
Figure 1.
Change in grade of inflammatory activity (top) and fibrosis staging score (bottom) between the paired biopsy specimens.white barsstriped barsP

Changes were analyzed in two categories that were defined by using the median time interval between obtaining paired biopsy specimens (<3 years [ ] and ≥ 3 years [ ]). Of these patients, 487 received interferon therapy (183 for sustained virologic response and 304 for nonsustained virologic response), and 106 patients were untreated. Values are expressed as the mean ± SE; the error bars represent 2 SEs. * < 0.01 by analysis of variance.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Persistent resolution of fibrosis in patients with sustained response to interferon therapy.solid linedashed linedashed and dotted line

Twelve patients with sustained virologic response (6 patients with stage F3 disease [ ], 5 patients with stage F2 disease [ ], and 1 patient with stage F1 disease [ ] at the initial biopsy) underwent two more liver biopsies after completion of interferon therapy. The fibrosis staging score is plotted in relation to time after the initial biopsy sample was obtained.

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Improvement in Liver Fibrosis in Patients with Hepatitis C Who Respond to Interferon Treatment

The summary below is from the full report titled “Histologic Improvement of Fibrosis in Patients with Hepatitis C Who Have Sustained Response to Interferon Therapy.”. It is in the 4 April 2000 issue of Annals of Internal Medicine (volume 132, pages 517-524). The authors are Y. Shiratori, F. Imazeki, M. Moriyama, M. Yano, Y. Arakawa, O. Yokosuka, T. Kuroki, S. Nishiguchi, M. Sata, G. Yamada, S. Fujiyama, H. Yoshida, and M. Omata.

Read More...

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)