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Low Cardiorespiratory Fitness and Physical Inactivity as Predictors of Mortality in Men with Type 2 Diabetes

Ming Wei, MD, MPH; Larry W. Gibbons, MD, MPH; James B. Kampert, PhD; Milton Z. Nichaman, MD, ScD; and Steven N. Blair, PED
[+] Article, Author, and Disclosure Information

From The Cooper Institute and The Cooper Clinic, Dallas, Texas; and Westat, Inc., Rockville, Maryland.

Grant Support: In part by grant AG06945 from the National Institute on Aging and grant HL62508 from the National Heart, Lung, and Blood Institute.

Requests for Single Reprints: Ming Wei, MD, The Cooper Institute, 12330 Preston Road, Dallas, TX 75230; e-mail, mwei@cooperinst.org.

Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org.

Current Author Addresses: Drs. Wei, Kampert, and Blair: The Cooper Institute, 12330 Preston Road, Dallas, TX 75230.

Dr. Gibbons: The Cooper Clinic, 12200 Preston Road, Dallas, TX 75230.

Dr. Nichaman: Westat, Inc., 1650 Research Boulevard, Rockville, MD 20850.

Author Contributions: Conception and design: M. Wei, L.W. Gibbons, S.N. Blair.

Analysis and interpretation of the data: M. Wei, L.W. Gibbons, S.N. Blair.

Drafting of the article: M. Wei, S.N. Blair.

Critical revision of the article for important intellectual content: M. Wei, L.W. Gibbons, J.B. Kampert, S.N. Blair, M.Z. Nichaman.

Final approval of the article: M. Wei, L.W. Gibbons, J.B. Kampert, S.N. Blair.

Provision of study materials or patients: M. Wei, L.W. Gibbons.

Statistical expertise: M. Wei, J.B. Kampert.

Obtaining of funding: M. Wei, S.N. Blair.

Administrative, technical, or logistic support: S.N. Blair.

Ann Intern Med. 2000;132(8):605-611. doi:10.7326/0003-4819-132-8-200004180-00002
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Exercise has become a standard therapy for patients with type 2 diabetes (1). Regular exercise improves conventional clinical risk factors, cardiorespiratory fitness, and components of the insulin resistance syndrome (26). However, it is unclear whether physical activity improves the prognosis of patients with diabetes. No data are available on the association of physical activity or cardiorespiratory fitness with mortality in patients with diabetes. The overall benefit of exercise for these patients is unclear, and some experts are concerned that macrovascular and microvascular complications may be worsened by an exercise program (1, 7). Some consider exercise only as a supplement to diet therapy (8). Studies have shown repeatedly that low cardiorespiratory fitness and physical inactivity are directly associated with cardiovascular disease and all-cause mortality (914), and our preliminary study with a small number of end points suggested that this association might persist across plasma glucose levels (15). In the current study, we evaluated the prospective association of cardiorespiratory fitness and physical inactivity with mortality in men who have type 2 diabetes.

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Grahic Jump Location
Survival curves for all-cause mortality by cardiorespiratory fitness category.

Data are from 1263 men with 180 all-cause deaths during 14 777 man-years of observation. The solid line represents fit participants and the dashed line represents unfit participants.

Grahic Jump Location




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Summary for Patients

Physical Fitness Predicts Survival in Men with Type 2 Diabetes

The summary below is from the full report titled “Low Cardiorespiratory Fitness and Physical Inactivity as Predictors of Mortality in Men with Type 2 Diabetes.”. It is in the 18 April 2000 issue of Annals of Internal Medicine (volume 132, pages 605-611). The authors are M. Wei, L.W. Gibbons, J.B. Kampert, M.Z. Nichaman, and S.N. Blair.


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