The full content of Annals is available to subscribers

Subscribe/Learn More  >
Updates |

Gene Therapy for Lung Disease: Hype or Hope?

Steven M. Albelda, MD; Rainer Wiewrodt, MD; and Jonathan B. Zuckerman, MD
[+] Article, Author, and Disclosure Information

From University of Pennsylvania Medical Center, Philadelphia, Pennsylvania.

For definitions of terms, see Glossary at end of text.

Acknowledgments: The authors thank Kate Darwin and Linda Kalb for assistance in preparing the manuscript.

Grant Support: This work was supported by grant PO1 66726 from the National Cancer Institute, National Institutes of Health; the Benjamin Shein Foundation for Humanity; and the Lunenfield Foundation (Dr. Albelda). Dr. Wiewrodt is a postdoctoral fellow of Mildred Scheel Stiftung für Krebsforschung der Deutschen Krebshilfe e.V. (grant D/98/02288).

Requests for Single Reprints: Steven M. Albelda, MD, 856 BRBII/III, 421 Curie Boulevard, Philadelphia, PA 19104; e-mail, albelda@mail.med.upenn.edu.

Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org.

Current Author Addresses: Dr. Albelda: 856 BRBII/III, 421 Curie Boulevard, Philadelphia, PA 19104.

Dr. Wiewrodt: 835 BRBII/III, 421 Curie Boulevard, Philadelphia, PA 19104.

Dr. Zuckerman: Pulmonary and Critical Care, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102.

Ann Intern Med. 2000;132(8):649-660. doi:10.7326/0003-4819-132-8-200004180-00008
Text Size: A A A

Approximately 10 years ago, advances in molecular genetics and gene transfer technology made possible the development of gene therapy, modification of the genetic makeup of cells for therapeutic purposes. Although gene therapy was originally proposed for treatment of inherited recessive disorders in which transfer of a normal copy of a single defective gene might prevent the development of disease or slow its progression (1), it soon became clear that reasonable targets for gene therapy extended beyond traditional genetic disorders into the realm of acquired diseases, such as vascular diseases and cancer. The concept of gene therapy now encompasses the treatment of any pathophysiologic state on the basis of the transfer of genetic material, including complementary DNA, full-length genes, RNA, or oligonucleotides.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.