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The Role of Bisphosphonates in Multiple Myeloma

Robert A. Kyle, MD
[+] Article and Author Information

Mayo Clinic and Mayo Foundation; Rochester, MN 55905 (Kyle)


Disclaimer: This editorial does not imply that Mayo Foundation endorses any of the products mentioned therein.

Disclosure: Dr. Kyle is on the Speaker's Bureau of OrthoBiotech, Schering-Plough, and Novartis. He also serves as a consultant to Hoffman-LaRoche.

Grant Support: In part by National Cancer Institute grant CA62242.

Requests for Single Reprints: Robert A. Kyle, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org.


Ann Intern Med. 2000;132(9):734-736. doi:10.7326/0003-4819-132-9-200005020-00009
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Multiple myeloma is characterized by bone destruction that often leads to some of the most debilitating manifestations of this disease: pain, hypercalcemia, osteopenia, pathologic fractures, and spinal cord compression. These clinical manifestations are due not only to myeloma deposits in the bone, which lead to focal bone destruction, but also to increased osteoporotic activity, resulting in bone resorption. Chemotherapy, even when successful, does not produce skeletal healing, and the dual risks of osteopenia and pathologic fracture persist. Fortunately, this often grim situation has at last begun to yield to pharmacologic intervention since the administration of bisphosphonates has been found to reduce the bone destruction caused by multiple myeloma.

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Figure.
Backbone chemical structure of a bisphosphonate.1Annual Reviews

Reprinted from Coukell and Markham with permission from .

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