The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

The Role of Bisphosphonates in Multiple Myeloma

Robert A. Kyle, MD
[+] Article, Author, and Disclosure Information

Mayo Clinic and Mayo Foundation; Rochester, MN 55905 (Kyle)

Disclaimer: This editorial does not imply that Mayo Foundation endorses any of the products mentioned therein.

Disclosure: Dr. Kyle is on the Speaker's Bureau of OrthoBiotech, Schering-Plough, and Novartis. He also serves as a consultant to Hoffman-LaRoche.

Grant Support: In part by National Cancer Institute grant CA62242.

Requests for Single Reprints: Robert A. Kyle, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org.

Ann Intern Med. 2000;132(9):734-736. doi:10.7326/0003-4819-132-9-200005020-00009
Text Size: A A A

Multiple myeloma is characterized by bone destruction that often leads to some of the most debilitating manifestations of this disease: pain, hypercalcemia, osteopenia, pathologic fractures, and spinal cord compression. These clinical manifestations are due not only to myeloma deposits in the bone, which lead to focal bone destruction, but also to increased osteoporotic activity, resulting in bone resorption. Chemotherapy, even when successful, does not produce skeletal healing, and the dual risks of osteopenia and pathologic fracture persist. Fortunately, this often grim situation has at last begun to yield to pharmacologic intervention since the administration of bisphosphonates has been found to reduce the bone destruction caused by multiple myeloma.

First Page Preview

View Large
First page PDF preview


Grahic Jump Location
Backbone chemical structure of a bisphosphonate.1Annual Reviews

Reprinted from Coukell and Markham with permission from .

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.