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Prolonged Prophylaxis after Joint Replacement: Another Step Sideways?

Bruce L. Davidson, MD, MPH; and Anthonie W.A. Lensing, MD, PhD
[+] Article, Author, and Disclosure Information

Note: Dr. Davidson is a consultant to companies that are developing antithrombotic drugs and is an investigator in clinical trials of these drugs. Funds generated by these activities go to Dr. Davidson's institution. Dr. Lensing is employed part-time by Organon Akzo Nobel, a company that produces antithrombotic and other types of drugs. He receives salary but not stock for this work.

Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org.

Current Author Addresses: Dr. Davidson: Pulmonary–Critical Care Medicine Section (C7-PUL), Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98101.

Dr. Lensing: Division of Vascular Medicine, Academic Medical Center, Meibergdreef 9, Box 22660, Amsterdam, the Netherlands.

Ann Intern Med. 2000;132(11):914-915. doi:10.7326/0003-4819-132-11-200006060-00011
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It is generally accepted that perioperative prophylaxis against venous thromboembolism is important for patients undergoing hip and knee replacement. Even before shortened hospitalizations, there was a tendency to extend prophylaxis into the outpatient setting. If prolonged prophylaxis after joint replacement were proven safe and effective for preventing not only clots but their clinical sequelae and were also convenient and inexpensive, it would not be controversial. Unfortunately, this is not the case.

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