0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Fatal Hepatorenal Failure Associated with Hydrazine Sulfate

Mark I. Hainer, DO; Naoky Tsai, MD; Steven T. Komura, MD; and Charles L. Chiu, PharmD
[+] Article and Author Information

Copyright ©2004 by the American College of Physicians


Ann Intern Med. 2000;133(11):877-880. doi:10.7326/0003-4819-133-11-200012050-00011
Text Size: A A A

Background: The Internet has revolutionized the manner in which patients obtain information about health care. This technology has also allowed patients to obtain directly both prescription and nonprescription therapies.

Objective: To report a case of fulminant hepatorenal failure associated with the use of hydrazine sulfate, an unregulated alternative remedy for cancer marketed on the Internet.

Design: Case report.

Setting: Academic medical center.

Patient: A 55-year-old man with maxillary sinus cancer.

Intervention: Self-medication with hydrazine sulfate.

Measurements: Serum liver and renal function tests; histologic evaluation of liver and kidney tissue.

Results: The patient developed hepatic encephalopathy, renal failure, and profound coagulopathy. He died after severe gastrointestinal hemorrhage developed. Autopsy revealed autolysis of the kidneys and submassive bridging necrosis of the liver.

Conclusion: Fatal hepatorenal failure may occur after the use of hydrazine sulfate. This fatal complication must be considered in anyone taking or contemplating the use of hydrazine sulfate.

Figures

Grahic Jump Location
Figure.
Submassive bridging necrosis of the liver.Top.Bottom.

Section of liver (hematoxylin–eosin stain; original magnification, ×40) with submassive bridging necrosis and island of residual hepatocytes. Section of liver (original magnification, ×100) with zone 1 centrilobular necrosis prominently involving areas adjacent to a central vein.

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)