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Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis

Bruce Y. Tung, MD; Mary J. Emond, PhD; Rodger C. Haggitt, MD; Mary P. Bronner, MD; Michael B. Kimmey, MD; Kris V. Kowdley, MD; and Teresa A. Brentnall, MD
[+] Article and Author Information

From University of Washington School of Medicine, Seattle, Washington.


†Deceased.

Note: This manuscript honors the memory of Rodger C. Haggitt, one of the coauthors. His contribution to these research efforts has been invaluable, and he will be deeply missed by colleagues, friends, and family.

Disclosure: Dr. Kowdley is on the Speakers' Bureau for Axcan Schwartz, a manufacturer of ursodiol, and receives research support from them. Axcan Schwartz is providing ursodiol for a prospective study by these authors of the chemoprotective role of ursodiol in ulcerative colitis.

Grant Support: By grants R01CA68124 and P01CA74184 from the National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.

Requests for Single Reprints: Teresa A. Brentnall, MD, Division of Gastroenterology, University of Washington, 1959 NE Pacific Street, Box 356424, Seattle, WA 98195; e-mail, teribr@u.washington.edu.

Current Author Addresses: Drs. Tung, Kimmey, Kowdley, and Brentnall: Division of Gastroenterology, University of Washington, 1959 NE Pacific Street, Box 356424, Seattle, WA 98195.

Dr. Emond: Department of Biostatistics, University of Washington, 1959 NE Pacific Street, Box 357232, Seattle, WA 98195.

Dr. Bronner: Department of Pathology, University of Washington, 1959 NE Pacific Street, Box 356100, Seattle, WA 98195.

Author Contributions: Conception and design: B.Y. Tung, M.J. Emond, R.C. Haggitt, M.P. Bronner, M.B. Kimmey, K.V. Kowdley, T.A. Brentnall.

Analysis and interpretation of the data: B.Y. Tung, M.J. Emond, T.A. Brentnall.

Drafting of the article: B.Y. Tung, M.J. Emond, T.A. Brentnall.

Critical revision of the article for important intellectual content: B.Y. Tung, M.J. Emond, R.C. Haggitt, M.P. Bronner, M.B. Kimmey, K.V. Kowdley, T.A. Brentnall.

Final approval of the article: B.Y. Tung, M.J. Emond, R.C. Haggitt, M.P. Bronner, M.B. Kimmey, K.V. Kowdley, T.A. Brentnall.

Provision of study materials or patients: M.B. Kimmey, K.V. Kowdley, T.A. Brentnall.

Statistical expertise: M.J. Emond.

Collection and assembly of data: B.Y. Tung, R.C. Haggitt, M.P. Bronner, M.B. Kimmey, K.V. Kowdley.


Ann Intern Med. 2001;134(2):89-95. doi:10.7326/0003-4819-134-2-200101160-00008
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Patients with ulcerative colitis have an increased risk for colorectal neoplasia; this risk approaches 0.5% to 1% per year of disease. The extent and duration of colitis, as well as age at onset of disease, are important risk factors for neoplastic progression (12). Primary sclerosing cholangitis is a chronic inflammatory disease of the biliary tract that occurs in 2% to 4% of patients with ulcerative colitis (35). Although the data are still controversial, most studies have shown that patients with ulcerative colitis and primary sclerosing cholangitis are at even higher risk for colonic neoplasia than are those with ulcerative colitis alone (611). The risk for colonic dysplasia or cancer in patients with ulcerative colitis and primary sclerosing cholangitis approaches 50% after 25 years of colitis (68).

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Summary for Patients

Ursodiol Is Associated with Fewer Precancerous Abnormalities of the Colon in Certain Patients with Ulcerative Colitis

The summary below is from the full report titled “Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis.” It is in the 16 January 2001 issue of Annals of Internal Medicine (volume 134, pages 89-95). The authors are BY Tung, MJ Emond, RC Haggitt, MP Bronner, MB Kimmey, KV Kowdley, and TA Brentnall.

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