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Silver Lining to the Cloud over Anorexogen-Related Cardiac Valvulopathy?

Martin St John Sutton, MD, FRCP
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Dr. Sutton: Hospital of the University of Pennsylvania; Philadelphia, PA 19104

Requests for Single Reprints:Martin St John Sutton, MD, FRCP, Cardiology Division, Hospital of the University of Pennsylvania, East Gates Building, Room 9017, Philadelphia, PA 19104.

Ann Intern Med. 2001;134(4):335-337. doi:10.7326/0003-4819-134-4-200102200-00018
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Pharmacologic appetite suppression has been used as an alternative strategy in the treatment of obesity for four decades. Anorexogen therapy is a more “attractive” method of losing weight than prolonged, often unsuccessful dietary restriction or gastric bypass or stapling procedures that facilitate gastric emptying. The appetite-suppressing effect of anorexogens is mediated by altering serotonin kinetics; phentermine inhibits clearance of serotonin in the lungs, and fenfluramine stimulates its release and blocks its neuronal reuptake. The common aim of the different therapies, used singly or in combination, is to reduce the morbidity due to coronary heart disease, stroke, and hypertension associated with obesity.

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