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Seizure Associated with Ginkgo biloba?

Philip J. Gregory, PharmD
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Pharmacist's Letter/Prescriber's Letter; Natural Medicines Comprehensive Database (Gregory)

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Ann Intern Med. 2001;134(4):344. doi:10.7326/0003-4819-134-4-200102200-00026
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ginko biloba, seizures and cavernous angiomas
Posted on November 11, 2004
James Langstaff
Conflict of Interest: None Declared

There have been scattered reports about the herb ginko biloba precipitating seizures and/or cerebral hemorrage, as mentioned in a 2001 letter in your journal. One fairly new development in epilepsy has been the diagnosis, with improved MRIs, of cavernous angiomas as being the cause of seizures.

I mention these two separate matters because I believe that there could be a connection, at least one worth exploring. Ginko reduces blood clotting and increases blood flow in the brain. Angiomas cause seizures when they bleed; noone seems to know why they bleed when they do. Couldn't ginko cause angiomas to be more likely to bleed? Has anyone investigated this connection?

Conflict of Interest:

None declared

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