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HIV Resistance Testing in Clinical Practice: A QALY-fied Success

Michael S. Saag, MD
[+] Article, Author, and Disclosure Information

Dr. Saag: University of Alabama at Birmingham; Birmingham, AL 35294-2050

Disclaimer: Dr. Saag has served as a consultant for three companies (Virco, ViroLogics, and Roche Diagnostics) involved in the development, manufacturing, or sale of products used in HIV resistance testing. In addition, he has collaborated with Virco and ViroLogics in clinical trials designed to evaluate the effectiveness of HIV resistance testing among patients followed in a clinical cohort.

Requests for Single Reprints: Michael S. Saag, MD, University of Alabama at Birmingham, CCB Room 178, 908 20th Street South, Birmingham, AL 35294-2050.

Ann Intern Med. 2001;134(6):475-477. doi:10.7326/0003-4819-134-6-200103200-00012
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Despite the significant advances in HIV therapy over the past 5 years, failure of highly active antiretroviral therapy (HAART) remains a significant problem. In a meta-analysis of 21 treatment groups from randomized clinical studies, only 46% of patients were able to reach the targeted HIV RNA viral load (<50 copies/mL) by 48 weeks (1). Because of virologic rebound or toxicity, the initial regimen ultimately fails even in most patients who are at first treated successfully. Therefore, HAART failure is common and should be anticipated by all clinicians caring for HIV-infected patients.

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