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Risk for Fracture in Women with Low Serum Levels of Thyroid-Stimulating Hormone

Douglas C. Bauer, MD; Bruce Ettinger, MD; Michael C. Nevitt, PhD; Katie L. Stone, PhD, Study of Osteoporotic Fractures Research Group
[+] Article and Author Information

From University of California, San Francisco, San Francisco, California; University of Pittsburgh, Pittsburgh, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; and Kaiser Permanente Medical Care Program, Oakland, California.


Grant Support: By Public Service Grant K08 AG00629 from the National Institute on Aging.

Requests for Single Reprints: Douglas C. Bauer, MD, University of California, San Francisco, 74 New Montgomery, Suite 600, San Francisco, CA 94105.

Current Author Addresses: Drs. Bauer, Nevitt, and Stone: University of California, San Francisco, 74 New Montgomery, Suite 600, San Francisco, CA 94105.

Dr. Ettinger: Division of Research, Kaiser Permanente, 3505 Broadway, 7th Floor, Oakland, CA 94611.

Author Contributions: Conception and design: D.C. Bauer.

Analysis and interpretation of the data: D.C. Bauer, B. Ettinger, M.C. Nevitt, K.L. Stone.

Drafting of the article: D.C. Bauer.

Critical revision of the article for important intellectual content: D.C. Bauer, B. Ettinger, M.C. Nevitt, K.L. Stone.

Final approval of the article: D.C. Bauer, B. Ettinger, M.C. Nevitt, K.L. Stone.

Statistical expertise: M.C. Nevitt, K.L. Stone.

Obtaining of funding: D.C. Bauer.

Administrative, technical, or logistic support: K.L. Stone.


Ann Intern Med. 2001;134(7):561-568. doi:10.7326/0003-4819-134-7-200104030-00009
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Osteoporosis and thyroid dysfunction are both common in older women; 8% to 13% of women older than 50 years of age have biochemical evidence of thyroid dysfunction (12), and 30% are osteoporotic according to bone density criteria (3). Although osteoporotic fractures have long been associated with florid hyperthyroidism (4) and, more recently, with a history of hyperthyroidism in older women (5), the relationship between biochemical evidence of excess thyroid hormone and fracture risk is not known (67).

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Summary for Patients

Too Much Thyroid Hormone Increases Risk for Bone Fractures

The summary below is from the full report titled “Risk for Fracture in Women with Low Serum Levels of Thyroid-Stimulating Hormone.” It is in the 3 April 2001 issue of Annals of Internal Medicine (volume 134, pages 561-568). The authors are DC Bauer, B Ettinger, MC Nevitt, and KL Stone, for the Study of Osteoporotic Fractures Research Group.

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