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Effects of Hormone Replacement Therapy on Serum Lipids in Elderly Women: A Randomized, Placebo-Controlled Trial

Ellen F. Binder, MD; Daniel B. Williams, MD; Kenneth B. Schechtman, PhD; Donna B. Jeffe, PhD; and Wendy M. Kohrt, PhD
[+] Article and Author Information

From Washington University School of Medicine, St. Louis, Missouri.


Acknowledgments: The authors thank Debbie Bronder, Kathie Obert, Timothy Meyer, Joseph Wilmot, Jil Yarasheski, and the staff of the General Clinical Research Center for technical assistance.

Grant Support: By a Claude Pepper Older Americans Independence Center Award (grant P01-AG13629) and a General Clinical Research Center grant (5-M01-RR00036) from the National Institutes of Health. Product support was provided by Wyeth-Ayerst Laboratories.

Requests for Single Reprints: Ellen F. Binder, MD, Division of Geriatrics and Gerontology, Washington University School of Medicine, 4488 Forest Park Boulevard, Suite 201, St. Louis, MO 63108; e-mail, ebinder@imgate.wustl.edu.

Current Author Addresses: Dr. Binder: Division of Geriatrics and Gerontology, Washington University School of Medicine, 4488 Forest Park Boulevard, Suite 201, St. Louis, MO 63108.

Dr. Williams: Department of Obstetrics and Gynecology, Washington University School of Medicine, 4444 Forest Park Boulevard, Suite 3100, St. Louis, MO 63108.

Dr. Schechtman: Division of Biostatistics, Washington University School of Medicine, Box 8067, 660 South Euclid, St. Louis, MO 63108.

Dr. Jeffe: Division of Health Behavior Research, Washington University School of Medicine, 4444 Forest Park Boulevard, Suite 6700, St. Louis, MO 63108.

Dr. Kohrt: Department of Medicine, Division of Geriatric Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B-179, Denver, CO 80262.

Author Contributions: Conception and design: E.F. Binder, K.B. Schechtman, W.M. Kohrt.

Analysis and interpretation of the data: E.F. Binder, K.B. Schechtman, W.M. Kohrt.

Drafting of the article: E.F. Binder, W.M. Kohrt.

Critical revision of the article for important intellectual content: E.F. Binder, K.B. Schechtman, W.M. Kohrt.

Final approval of the article: E.F. Binder, D.B. Jeffe, K.B. Schechtman, W.M. Kohrt.

Statistical expertise: K.B. Schechtman.

Obtaining of funding: E.F. Binder, W.M. Kohrt.

Administrative, technical, or logistic support: E.F. Binder, D.B. Williams, D.B. Jeffe, W.M. Kohrt.

Collection and assembly of data: E.F. Binder, D.B. Jeffe.


Ann Intern Med. 2001;134(9_Part_1):754-760. doi:10.7326/0003-4819-134-9_Part_1-200105010-00012
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Eighty percent of deaths due to coronary heart disease (CHD) occur in persons older than 65 years of age, and CHD accounts for 50% of all deaths among persons older than 85 years of age (1). Coronary disease is the leading cause of death among older women (2). Because of the higher rates of CHD-related morbidity and death and the higher prevalence of cardiovascular risk factors among elderly persons, the attributable risk for any individual risk factor may be higher in elderly than in younger adults (34). Modification of risk factors in this older age group therefore may strongly affect morbidity and mortality from CHD. Low serum levels of high-density lipoprotein (HDL) cholesterol are among the risk factors that have been predictive of death from CHD among adults older than 70 years of age, particularly among women (5). Therefore, interventions that target hypercholesterolemia may benefit older women.

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Summary for Patients

Effects of Hormone Replacement Therapy on Cholesterol Levels in Elderly Women

The summary below is from the full report titled “Effects of Hormone Replacement Therapy on Serum Lipids in Elderly Women. A Randomized, Placebo-Controlled Trial.” It is in the 1 May 2001 issue of Annals of Internal Medicine (volume 134, pages 754-760). The authors are EF Binder, DB Williams, KB Schechtman, DB Jeffe, and WM Kohrt.

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