In 65 patients, the abnormal bone marrow cells disappeared, and there was no evidence of continued production of amyloid. Fifty of the 65 patients lived longer than 12 months. Kidney function improved in about one third of the 50 survivors and in more than two thirds of the 23 persons who no longer had evidence of amyloid production. While this therapy was successful in some patients, more than 20% had serious side effects from the intensive therapy. Side effects included immediately worsening kidney function, fluid in the lungs, infection, and bleeding.