0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Benefits of Pravastatin on Cardiovascular Events and Mortality in Older Patients with Coronary Heart Disease Are Equal to or Exceed Those Seen in Younger Patients: Results from the LIPID Trial

David Hunt, MD; Peta Young, MPH; John Simes, MD; Wendy Hague, , MBBS; Stewart Mann, DM; Dwain Owensby, MD; Geoffrey Lane, , MBBS; Andrew Tonkin, MD, LIPID Investigators
[+] Article and Author Information

From the Royal Melbourne Hospital and National Heart Foundation, Melbourne, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Wollongong Hospital, Wollongong, and Fremantle Hospital, Perth, Australia; and Hutt Hospital, Lower Hutt, New Zealand.


Grant Support: The LIPID trial was supported by a grant from Bristol-Myers Squibb and was coordinated independently by the National Health and Medical Research Council Clinical Trials Centre under the auspices of the National Heart Foundation of Australia.

Acknowledgments: The authors thank the LIPID study investigators and coordinators at each of the participating centers (listed in reference 12); the patients from the participating centers, for their commitment to the study; and Rhana Pike, for assistance with the manuscript.

Requests for Single Reprints: John Simes, MD, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown NSW 1450, Australia; e-mail, enquiry@ctc.usyd.edu.au.

Current Author Addresses: Dr. Hunt: Department of Cardiology, Royal Melbourne Hospital, Grattan Street, Parkville Vic 3050, Australia.

Ms. Young, Dr. Simes, and Dr. Hague: National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown NSW 1450, Australia.

Dr. Mann: Cardiology Department, Hutt Hospital, Private Bag 31907, Lower Hutt, New Zealand.

Dr. Owensby: Cardiology Department, Wollongong Hospital, Crown Street, Wollongong NSW 2500, Australia.

Dr. Lane: Department of Cardiovascular Medicine, Fremantle Hospital, PO Box 480, Fremantle WA 6160, Australia.

Dr. Tonkin: National Heart Foundation of Australia, 411 King Street, West Melbourne Vic 3003, Australia.

Author Contributions: Conception and design: D. Hunt, J. Simes, A. Tonkin.

Analysis and interpretation of the data: D. Hunt, P. Young, J. Simes, W. Hague, S. Mann, D. Owensby.

Drafting of the article: D. Hunt, P. Young, J. Simes, G. Lane. Critical revision for important intellectual contact: D. Hunt, J. Simes, W. Hague, S. Mann, D. Owensby, G. Lane, A. Tonkin.

Final approval of the article: D. Hunt, P. Young, J. Simes, W. Hague, S. Mann, D. Owensby, G. Lane, A. Tonkin.

Statistical expertise: P. Young, J. Simes.

Obtaining of funding: D. Hunt, J. Simes, A. Tonkin. Administrative, technical or logistic support: J. Simes.

Collection and assembly of data: J Simes.


Ann Intern Med. 2001;134(10):931-940. doi:10.7326/0003-4819-134-10-200105150-00007
Text Size: A A A

Coronary heart disease is the major cause of death in middle-aged and older persons (13). Blood cholesterol level is a major risk factor for coronary heart disease, and although it was previously thought to be of less prognostic importance in older people (45), it is now accepted as a major risk factor in that population (68).

First Page Preview

View Large
/>
First page PDF preview

Figures

Grahic Jump Location
Figure 1.
Relative risks for coronary events according to age group in the Long-Term Intervention with Pravastatin in Ischaemic Disease study.

CABG = coronary artery bypass grafting; CHD = coronary heart disease; CVD = cerebrovascular disease; MI = myocardial infarction; PTCA = percutaneous transluminal coronary angioplasty.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Effects of pravastatin (dotted line) and placebo (solid line) on all-cause mortality (top) and coronary events (coronary heart disease death and nonfatal myocardial infarction) (bottom) among patients 31 to 64 years of age and patients 65 to 75 years of age.
Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Benefits of Lowering Cholesterol Levels in Older Patients

The summary below is from the full report titled “Benefits of Pravastatin on Cardiovascular Events and Mortality in Older Patients with Coronary Heart Disease Are Equal to or Exceed Those Seen in Younger Patients: Results from the LIPID Trial.” It is in the 15 May 2001 issue of Annals of Internal Medicine (volume 134, pages 931-940). The authors are D Hunt, P Young, J Simes, W Hague, S Mann, D Owensby, G Lane, and A Tonkin, for the LIPID Investigators.

Read More...

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)