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Incidence of Malignant Disease in Biopsy-Proven Inflammatory Myopathy: A Population-Based Cohort Study

Rachelle Buchbinder, MBBS(Hons), MSc; Andrew Forbes, PhD; Stephen Hall, MBBS(Hons), BMedSci; Xenia Dennett, PhD; and Graham Giles, PhD, MSc
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From Cabrini Medical Centre, Malvern, and Monash University, Melbourne University, and Cancer Control Research Institute of the Anti-Cancer Council of Victoria, Melbourne, Australia.

Grant Support: By a grant from the Arthritis Foundation of Australia.

Requests for Single Reprints: Rachelle Buchbinder, MBBS (Hons), MSc, Suite 41, Cabrini Medical Centre, 183 Wattletree Road, Malvern, Victoria, Australia 3144; e-mail, rachelle.buchbinder@med.monash.edu.au.

Current Author Addresses: Dr. Buchbinder: Department of Clinical Epidemiology, Suite 41, Cabrini Medical Centre, 183 Wattletree Road, Malvern, Victoria, Australia 3144.

Dr. Forbes: Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital Campus, Commercial Road, Prahran, Victoria, Australia 3181.

Dr. Hall: Suite 43, Cabrini Medical Centre, 183 Wattletree Road, Malvern, Victoria, Australia 3144.

Dr. Dennett: State Neuropathology Service, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia 3010.

Dr. Giles: Cancer Epidemiology Centre and Victorian Cancer Registry, Cancer Control Research Institute of the Anti-Cancer Council of Victoria, 100 Drummond Street, Carlton South, Victoria, Australia 3053.

Author Contributions: Conception and design: R. Buchbinder, A. Forbes, S. Hall.

Analysis and interpretation of the data: R. Buchbinder, A. Forbes.

Drafting of the article: R. Buchbinder, A. Forbes.

Critical revision of the article for important intellectual content: R. Buchbinder, A. Forbes, S. Hall, X. Dennett, G. Giles.

Final approval of the article: R. Buchbinder, X. Dennett, G. Giles.

Provision of study materials or patients: R. Buchbinder, X. Dennett, G. Giles.

Statistical expertise: A. Forbes.

Obtaining of funding: R. Buchbinder.

Administrative, technical, or logistic support: R. Buchbinder, G. Giles.

Collection and assembly of data: R. Buchbinder, X. Dennett, G. Giles.

Ann Intern Med. 2001;134(12):1087-1095. doi:10.7326/0003-4819-134-12-200106190-00008
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Although an association between polymyositis and dermatomyositis and malignant disease was first suggested in 1916 (12), the validity and the magnitude of this association continue to be questioned (311). Clinical and methodologic factors that have hindered resolution of this question have included diagnostic suspicion and referral bias; the legitimacy of the diagnosis of myositis and, in particular, the distinction between polymyositis and dermatomyositis; studies with small samples and short duration of follow-up; and lack of an appropriate control group.

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Grahic Jump Location
Figure 1.
Time between diagnosis of polymyositis (top) or dermatomyositis (bottom) and diagnosis of malignant disease.
Grahic Jump Location




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Summary for Patients

Associations between Cancer and Inflammation of the Muscles

The summary below is from the full report titled “Incidence of Malignant Disease in Biopsy-Proven Inflammatory Myopathy. A Population-Based Cohort Study.” It is in the 19 June 2001 issue of Annals of Internal Medicine (volume 134, pages 1087-1095). The authors are R Buchbinder, A Forbes, S Hall, X Dennett, and G Giles.


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