With this issue, I end my editorship of Annals. When I entered the editor's world six and a half years ago, I shared the common view that editors are in the enviable position of being able to shape a journal, choosing among submitted papers, inviting others, and publishing editorial opinions. Editing Annals has certainly given me that opportunity and more, including the launch of the journal's first fully functional Web site (www.annals.org); publication of supplements on topics ranging from diabetes and hemochromatosis, to the use of large databases, and research on symptoms; as well as series on systematic reviews, physicians as leaders, ambulatory care, and drugs and drug therapy. On my watch, we introduced new journal features, including the Update series, Medical Writings, and On Being a Patient, and redesigned the print journal.