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Highly Active Antiretroviral Therapy Decreases Mortality and Morbidity in Patients with Advanced HIV Disease

Edward L. Murphy, MD, MPH; Ann C. Collier, MD; Leslie A. Kalish, ScD; Susan F. Assmann, PhD; Michael F. Para, MD; Timothy P. Flanigan, MD; Princy N. Kumar, MD; Letty Mintz, ANP; Frances R. Wallach, MD; George J. Nemo, PhD, Viral Activation Transfusion Study Investigators*
[+] Article and Author Information

From University of California, San Francisco, San Francisco, California; University of Washington, Seattle, Washington; New England Research Institutes, Watertown, Massachusetts; Ohio State University, Columbus, Ohio; Miriam Hospital, Brown University, Providence, Rhode Island; Georgetown University, Washington, D.C.; Mount Sinai Medical Center, New York, New York; and National Heart, Lung, and Blood Institute, Bethesda, Maryland.


Acknowledgments: The authors thank the patients and the transfusion service and hospital nursing personnel.

Grant Support: By National Heart, Lung, and Blood Institute contract N01-HB-57121.

Requests for Single Reprints: Edward L. Murphy, MD, MPH, Department of Laboratory Medicine, University of California, San Francisco, Box 0884, San Francisco, CA 94143-0884; e-mail, murphy@itsa.ucsf.edu.

Current Author Addresses: Dr. Murphy: Department of Laboratory Medicine, University of California, San Francisco, Box 0884, San Francisco, CA 94143-0884

Dr. Collier: University of Washington, Box 359929, 325 9th Avenue, Seattle, WA 98104.

Dr. Kalish and Assmann: New England Research Institute, 9 Galen Street, Watertown, MA 02472.

Dr. Para: Ohio State University, 456 West 10th Avenue, Columbus, OH 43210.

Dr. Flanigan: Brown University Medical School, Miriam Hospital, 164 Summit Avenue, Providence, RI 02906-2853.

Dr. Kumar: Georgetown University Medical Center, 3800 Reservoir Road, Washington, DC 20007.

Ms. Mintz and Dr. Wallach: Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029.

Dr. Nemo: National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892.

Author Contributions: Conception and design: E.L. Murphy, A.C. Collier, L.A. Kalish, S.F. Assmann, M.F. Para, T.P. Flanigan, P.N. Kumar.

Analysis and interpretation of the data: E.L. Murphy, A.C. Collier, L.A. Kalish, S.F. Assmann, P.N. Kumar.

Drafting of the article: E.L. Murphy, S.F. Assmann, P.N. Kumar.

Critical revision of the article for important intellectual content: E.L. Murphy, A.C. Collier, L.A. Kalish, S.F. Assmann, M.F. Para, T.P. Flanigan, P.N. Kumar.

Final approval of the article: E.L. Murphy, A.C. Collier, L.A. Kalish, S.F. Assmann, M.F. Para, T.P. Flanigan, P.N. Kumar, G.J. Nemo.

Provision of study materials or patients: A.C. Collier, M.F. Para, P.N. Kumar, L. Mintz, F.R. Wallach.

Statistical expertise: L.A. Kalish, S.F. Assmann.

Obtaining of funding: A.C. Collier, L.A. Kalish, G.J. Nemo.

Administrative, technical, or logistic support: A.C. Collier, F.R. Wallach, G.J. Nemo.

Collection and assembly of data: E.L. Murphy, A.C. Collier, T.P. Flanigan, P.N. Kumar, L. Mintz.


Ann Intern Med. 2001;135(1):17-26. doi:10.7326/0003-4819-135-1-200107030-00005
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The introduction of combination antiretroviral therapy for HIV infection revolutionized treatment of AIDS and HIV disease. Such treatment, which usually includes two nucleoside analogue inhibitors of HIV reverse transcriptase and at least one HIV protease inhibitor or non-nucleoside inhibitor of HIV reverse transcriptase, is called highly active antiretroviral therapy (HAART). Early cohort and registry-based studies showed a lower incidence of AIDS and decreased rates of AIDS-related mortality after the introduction of HAART in late 1995 in the United States (13), France (4), Australia (5), Germany (6), and Switzerland (7).

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Figure.
Prevalence of highly active antiretroviral therapy (HAART) and other antiretroviral therapy (ARV) among patients in the Viral Activation Transfusion Study, by date.

The number of patients being followed at each time point is shown below the graph.

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Summary for Patients

Using Multiple Drugs in Combination Helps Patients with Advanced AIDS

The summary below is from the full report titled “Highly Active Antiretroviral Therapy Decreases Mortality and Morbidity in Patients with Advanced HIV Disease.” It is in the 3 July 2001 issue of Annals of Internal Medicine (volume 135, pages 17-26). The authors are EL Murphy, AC Collier, LA Kalish, SF Assmann, MF Para, TP Flanigan, PN Kumar, L Mintz, FR Wallach, and GJ Nemo, for the Viral Activation Transfusion Study Investigators.

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