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Managing Excessive Warfarin Anticoagulation

Henry I. Bussey, PharmD
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Clinical Pharmacy Programs Dr. Bussey: San Antonio, TX 78229-3900

Requests for Single Reprints: Henry I. Bussey, PharmD, Clinical Pharmacy Programs, MSC:6220, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900.

Ann Intern Med. 2001;135(6):460-462. doi:10.7326/0003-4819-135-6-200109180-00015
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Warfarin is very effective in preventing thromboembolic events, but it is probably one of the most dangerous drugs that is used on a long-term basis. Warfarin reduces the risk for stroke in atrial fibrillation by approximately 85%, but almost one half of eligible patients do not receive such therapy (12). Apparently, many clinicians do not use warfarin for fear of bleeding complications.

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