Summaries for Patients |

Genes and HIV Progression FREE

[+] Article, Author, and Disclosure Information

The summary below is from the full report titled “Effects of CCR5-Δ32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data.” It is in the 6 November 2001 issue of Annals of Internal Medicine (volume 135, pages 782-795). The authors are JPA Ioannidis, PS Rosenberg, JJ Goedert, LJ Ashton, TL Benfield, SP Buchbinder, RA Coutinho, J Eugen-Olsen, T Gallart, TL Katzenstein, LG Kostrikis, H Kuipers, LG Louie, SA Mallal, JB Margolick, OP Martinez, L Meyer, NL Michael, E Operskalski, G Pantaleo, GP Rizzardi, H Schuitemaker, HW Sheppard, GJ Stewart, ID Theodorou, H Ullum, E Vicenzi, D Vlahov, D Wilkinson, C Workman, J-F Zagury, and TR O'Brien, for the International Meta-Analysis of HIV Host Genetics.

Ann Intern Med. 2001;135(9):S52. doi:10.7326/0003-4819-135-9-200111060-00004
Text Size: A A A

What is the problem and what is known about it so far?

There are more than 30,000 genes in a human body cell. Each gene in a pair is located in the same place on a pair of similar chromosomes. Genes have alternate forms that are known as alleles. A gene may have a few or several hundred different alleles. Different alleles account for inherited differences between individuals, such as varying eye color. Alleles may also play a part in the cause and progression of diseases. For example, individuals differ in the likelihood of developing AIDS after becoming infected with HIV-1. Differences in alleles probably cause these differences between individuals. However, whether specific alleles promote progression to AIDS has not been clear.

Why did the researchers do this particular study?

To see whether certain genetic alleles are associated with progression of HIV-1 disease.

Who was studied?

4504 people with HIV-1 infection who were of African or European descent.

How was the study done?

The researchers analyzed information from previous studies that had tested for associations between genetic alleles and the course of HIV-1 infection. The studies had been conducted by 19 groups of researchers in the United States, Europe, and Australia. In each study, the authors periodically checked a group of people with HIV-1 infection to see who developed AIDS or died. All study participants had had special genetic testing to determine whether or not they carried particular alleles (CCR5-Δ 32, CCR2-64I, SDF-1 3′A) that have been suspected to affect progression of HIV infection. The authors combined the results from all of the studies in a special way (individual-patient–based meta-analysis) to see which alleles were associated with AIDS or death.

What did the researchers find?

The CCR5-Δ 32 and CCR2-64I alleles were associated with a decreased risk for progression to AIDS and a decreased risk for death. These alleles did not protect against death once AIDS had developed. In contrast to some prior reports, having the SDF-1 3′A allele was not associated with progression to AIDS or death.

What were the limitations of the study?

Some patients had had HIV-1 infection for varying periods of time when they entered the studies. Patients who had rapidly progressed from HIV-1 infection to AIDS or death may not have been included in the study. This might mean that alleles responsible for rapid progression or death were not identified. Moreover, only patients of African or European descent were included in the meta-analysis.

What are the implications of the study?

Particular alleles (CCR5-Δ 32 and CCR2-64I) protect against disease progression in patients with HIV-1 infection. Drugs that imitate the effect of these alleles might delay progression of HIV infection. Whether and how such alleles influence response to antiviral therapies are currently being studied.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.