Sorting through the potential benefits and harms of postmenopausal hormone use can be confusing. For example, benefits include less osteoporosis (weakening of the bones) and fewer menopausal symptoms. Harms include small increases in risk for breast, uterine, and ovarian cancer and an increased risk for stroke and blood clots in the legs. Whether postmenopausal hormone use helps prevent heart disease is unclear. One recent study showed that therapy with a particular hormone (conjugated equine estrogen plus medroxyprogesterone, known by the brand name Prempo) for 1 to 3 years did not decrease repeated episodes of heart disease in older postmenopausal women who had known preexisting heart disease. Now physicians are uncertain about whether hormone use prevents atherosclerosis (narrowing of the arteries due to build up of fatty substances and cholesterol), particularly in healthy postmenopausal women without known heart disease.