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Change in Lung Function and Morbidity from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes: A Longitudinal Study of the General Population

Morten Dahl, MD; Anne Tybjærg-Hansen, MD, DMSc; Peter Lange, MD, DMSc; Jørgen Vestbo, MD, DMSc; and Børge G. Nordestgaard, MD, DMSc
[+] Article and Author Information

From Herlev University Hospital, Herlev; Copenhagen University Hospital and Bispebjerg University Hospital, Copenhagen; and Hvidovre University Hospital, Hvidovre, Denmark.


Acknowledgments: The authors thank Anne-Merete Bengtsen, Charlotte Worm, and Hanne Damm for technical assistance and the participants of the Copenhagen City Heart Study for their willingness to participate.

Grant Support: By the Danish Lung Association, the Danish Heart Foundation, the Danish Medical Research Council, Løvens Kemiske Fabrik's Forskningsfond, and the Beckett Fund.

Requests for Single Reprints: Børge G. Nordestgaard, MD, DMSc, Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark; e-mail, brno@herlevhosp.kbhamt.dk.

Current Author Addresses: Drs. Dahl and Nordestgaard: Department of Clinical Biochemistry 54M1, Herlev University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.

Dr. Tybjærg-Hansen: Department of Clinical Biochemistry KB3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark.

Drs. Lange and Vestbo: Department of Respiratory Medicine 121, Hvidovre University Hospital, Kettegård Allé 30, DK-2650 Hvidovre, Denmark.

Author Contributions: Conception and design: M. Dahl, A. Tybjærg-Hansen, P. Lange, J. Vestbo, B.G. Nordestgaard.

Analysis and interpretation of the data: M. Dahl, A. Tybjærg-Hansen, P. Lange, J. Vestbo, B.G. Nordestgaard.

Drafting of the article: M. Dahl.

Critical revision of the article for important intellectual content: M. Dahl, A. Tybjærg-Hansen, P. Lange, J. Vestbo, B.G. Nordestgaard.

Final approval of the article: M. Dahl, A. Tybjærg-Hansen, P. Lange, J. Vestbo, B.G. Nordestgaard.

Statistical expertise: M. Dahl, A. Tybjærg-Hansen, P. Lange, J. Vestbo, B.G. Nordestgaard.

Obtaining of funding: A. Tybjærg-Hansen, B.G. Nordestgaard.

Collection and assembly of data: M. Dahl, A. Tybjærg-Hansen, B.G. Nordestgaard.


Ann Intern Med. 2002;136(4):270-279. doi:10.7326/0003-4819-136-4-200202190-00006
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Of the 9187 persons in our analysis who underwent genotyping, 592 had measurements for plasma α1-antitrypsin level and 6428 had values for annual decrease in FEV1 (spirometry was performed in these participants at two or three examinations); 9159 persons were examined for airway obstruction (spirometry was performed at least once). Follow-up for COPD hospitalization and death was complete for all 9187 participants.

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Figure.
Kaplan-Meier curves showing combined cumulative incidence of hospitalization and death due to chronic obstructive pulmonary disease (COPD) during follow-up.MM

Only selected genotypes with COPD outcomes different from the genotype are shown. The number of persons at risk at the beginning of each 5-year period is shown at the bottom of the figure.

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Summary for Patients

Lung Function and Death from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes

The summary below is from the full report titled “Change in Lung Function and Morbidity from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes: A Longitudinal Study of the General Population.” It is in the 19 February 2002 issue of Annals of Internal Medicine (volume 136, pages 270-279). The authors are M Dahl, A Tybjærg-Hansen, P Lange, J Vestbo, BG Nordestgaard.

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