Good evidence suggests that health care providers who routinely ask patients about sad feelings will identify more adults with depression. There is no evidence that one method of screening for depression works better than another. It does appear that two questions—1] Over the past 2 weeks, have you ever felt down, depressed, or hopeless? 2) Over the past 2 weeks, have you felt little interest or pleasure in doing things?—can identify patients with depression as well as longer sets of questions can. Good evidence shows that treating depression with counseling, medications, or both improves patient outcomes. Research on how frequently depression screening should occur is lacking. There is limited evidence about how well depression screening works in children and adolescents.