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Update on Spondyloarthropathies

Muhammad Asim Khan, MD, FRCP
[+] Article, Author, and Disclosure Information

From Case Western Reserve University, Cleveland, Ohio.

Grant Support: By an investigator subgrant under National Institutes of Health grant 1 RO1 AR46208-01, CFDA 93.846, UT 201.2.5101.

Requests for Single Reprints: Muhammad Asim Khan, MD, FRCP, Case Western Reserve University, MetroHealth Medical Center, Division of Rheumatology, 2500 MetroHealth Drive, Cleveland, OH 44109.

Ann Intern Med. 2002;136(12):896-907. doi:10.7326/0003-4819-136-12-200206180-00011
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Spondyloarthropathies constitute a cluster of interrelated and overlapping chronic inflammatory rheumatic diseases that includes ankylosing spondylitis (the most typical form of spondyloarthropathy); reactive arthritis; arthritis associated with psoriasis, Crohn disease, and ulcerative colitis; and a form of juvenile chronic arthritis (18). Their clinical spectrum is much wider than previously realized, and some additional, less clearly defined types are categorized as undifferentiated spondyloarthritis (910). Clear differentiation among these various forms, especially in their early stages, may not always be possible owing to overlapping clinical features. However, lack of differentiation does not usually affect treatment decisions.

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