0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Use of the Electrocardiograph-Based Thrombolytic Predictive Instrument To Assist Thrombolytic and Reperfusion Therapy for Acute Myocardial Infarction: A Multicenter, Randomized, Controlled, Clinical Effectiveness Trial

Harry P. Selker, MD, MSPH; Joni R. Beshansky, RN, MPH; John L. Griffith, PhD, TPI Trial Investigators*
[+] Article and Author Information

From Tufts–New England Medical Center, Boston, Massachusetts.


Acknowledgments: The authors thank the regional and site coordinators at the study hospitals: Del Blank, RN, MBA, Regional Coordinator, Franklin Medical Center, Mary Lane Hospital, Cooley Dickinson Hospital, and Noble Hospital; Patricia Mitchell, RN, Regional Coordinator, Boston City Hospital, Carney Hospital, and University Hospital; David Kwon, Site Coordinator, Cedars-Sinai Medical Center; Marge Erwin, RN, Regional Coordinator, Bess Kaiser Medical Center and Sunnyside Medical Center; M. Elizabeth Hearon, Site Coordinator, New England Medical Center; Donna Cimini, RN, Site Coordinator, Rhode Island Hospital; Mary Frances Ward, RN, Regional Coordinator, North Shore University Hospital–Glen Cove, Huntington Hospital, and University Hospital–Stony Brook; Mary Jensen, RN, Regional Coordinator, Presbyterian/St. Luke's Medical Center and Swedish Hospital; and Tami Owen, RN, BSN, Rural Regional Coordinator, Regional West Medical Center, Chadron Community Hospital, Box Butte General Hospital, Lincoln Community Hospital, Plains Medical Center, Silverheels Health Center, Timberline Medical Center, Memorial Hospital, Southeast Colorado Hospital, Decatur County Hospital, and Memorial Health Center.

They also thank the staff of the study hospitals: Mary Guzik, RN, Mary Lane Hospital; Noeline Woolrich, RN, Cooley Dickinson Hospital; Sophie Killips, Noble Hospital; Sheilah Bernard, MD, Clara Berty Safi, RN, and Sue Fish, PharmD, MPH, Boston City Hospital; John Kim, Prediman K. Shah, MD, Joel Geiderman, MD, Linda Verraster, RN, and Mary Flores, RN, Cedars-Sinai Medical Center; Marlene McKenzie, RN, Debbie Towery, RN, Judi Donnelly, MS, RN, CCRN, and Michael Blahnik, MD, Bess Kaiser Medical Center; Jeremy K. Ota, MD, Kenneth Nisbet, MD, and Arthur Hayward, MD, Sunnyside Medical Center; Jo Anne Capobianco, RN, and Elayne Palumbo, Rhode Island Hospital; Doreen O'Grady, RN, North Shore University Hospital–Glen Cove; Kathy Stark, RN, and Lynne Streekre, RN, Huntington Hospital; Sharon Valentine, RN, University Hospital–Stony Brook; Linda Hackley, Presbyterian/St. Luke's Medical Center and Swedish Hospital; Brett Hoppes, Bonin Lager, RN, Alice Maupin, Ward Krichau, Dee Vogel, RN, BSN, and Kathy Jacobson, RN, BSN, Regional West Medical Center; Jean Martin, CRT, RCP, and Harold Krueger Sr., Chadron Community Hospital; Jan Hoffman Loomis, RN, T.J. Padden, Vicki Mentele, and Carolyn Jones, Box Butte General Hospital; Gwen Schroeder and Mary Thompson, Lincoln Community Hospital; Linda Messer and Debbie Olesen, Plains Medical Center; Patty Schoville, NP, and Judy Peck, RN, Silverheels Health Center; Sally Hartman, RN, and Deborah Marshbanks, RN, Timberline Medical Center; Rebecca Warren, RN, David Moore, Anna James, and Annessa Cook, Memorial Hospital; Marla Baxter, RN, and Annie Dukes, BSN, MBA, JD, Southeast Colorado Hospital; Linda Stanley, RN, Doreen Olson, and Kim Hardman, Decatur County Hospital; and Larry Kelly, Mray Pettit, and Rex Walker, Memorial Health Center.

The authors thank the members of the Data Monitoring and Safey Committee: Alexa Beiser, PhD; Costas T. Lambrew, MD; and Tohmas J. Ryan, MD, Chair. They also thank Jame D. Scott, ScD, U.S. Agency for Healthcare Research and Quality (formerly U.S. Agency for Health Care Policy and Research), Project Officer, for support; Daniel B. Stryer, MD, for suggestions on the manuscript; and Julie Burt for manuscript preparation.

Grant Support: By grant R01 HS 08212 from the Agency for Healthcare Research and Quality and in part by grant M01 RR00054 from the General Clinical Research Center at New England Medical Center funded by the National Center for Research Resources, National Institutes of Health.

Requests for Single Reprints: Harry P. Selker, MD, MSPH, Tufts–New England Medical Center, Division of Clinical Care Research, 750 Washington Street #63, Boston, MA 02111; e-mail, hselker@lifespan.org.

Current Author Addresses: Drs. Selker and Griffith and Ms. Beshansky: Tufts–New England Medical Center, Division of Clinical Care Research, 750 Washington Street #63, Boston, MA 02111.

Author Contributions: Conception and design: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Analysis and interpretation of the data: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Drafting of the article: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Critical revision of the article for important intellectual content: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Final approval of the article: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Provision of study materials or patients: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Statistical expertise: H.P. Selker, J.R. Beshansky.

Obtaining of funding: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Administrative, technical, or logistic support: H.P. Selker, J.R. Beshansky, J.L. Griffith.

Collection and assembly of data: H.P. Selker, J.R. Beshansky, J.L. Griffith.


Ann Intern Med. 2002;137(2):87-95. doi:10.7326/0003-4819-137-2-200207160-00006
Text Size: A A A

As shown in the Figure, a total of 8919 patients with possible AMI were screened for study eligibility. Of 3266 eligible patients with AMI, 2879 (88%) consented to participate; 1237 (43%) had AMI with ST-segment elevation detected and were randomly assigned to study groups by the electrocardiograph. Of these 1237 patients, 40 (3.2%) had two different randomization assignments and thus were excluded from the trial. Of the 1197 patients included in the trial, those assigned to the control group (n = 587) and those assigned to the TPI group (n = 610) were similar, except for trends toward more previous coronary artery disease in the control group and more diabetes in the TPI group (Table 1). The 1642 consenting patients with AMI without ST-segment elevation were included in a “non-trial” registry.

First Page Preview

View Large
/>
First page PDF preview

Figures

Grahic Jump Location
Figure.
Patient inclusion.

AMI = acute myocardial infarction; TPI = Thrombolytic Predictive Instrument.

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

A Decision Aid for Recognizing and Treating Heart Attacks Quickly

The summary below is from the full report titled “Use of the Electrocardiograph-Based Thrombolytic Predictive Instrument To Assist Thrombolytic and Reperfusion Therapy for Acute Myocardial Infarction. A Multicenter, Randomized, Controlled, Clinical Effectiveness Trial.” It is in the 16 July 2002 issue of Annals of Internal Medicine (volume 137, pages 87-95). The authors are HP Selker, JR Beshansky, and JL Griffith, for the TPI Trial Investigators.

Read More...

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)