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Angiotensin-Converting Enzyme Gene Polymorphism Is Associated with Vulnerability to Alcoholic Cardiomyopathy

Joaquim Fernández-Solà, MD; Josep María Nicolás, MD; Josep Oriola, PhD; Emilio Sacanella, MD; Ramón Estruch, MD; Emanuel Rubin, MD; and Alvaro Urbano-Márquez, MD
[+] Article and Author Information

Grant Support: By Fondo de Investigación Sanitaria (grants 98/0330, 99/0115, and 99/0318) and Generalitat de Catalunya (grant CUR 2001/SGR/00379).

Requests for Single Reprints: Emanuel Rubin, MD, Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, 1020 Locust Street, Suite 279, Philadelphia, PA 19107; e-mail, emanuel.rubin@mail.tju.edu.

Potential Financial Conflicts of Interest:Grants Received: J. Fernández-Solà, J.M. Nicolás, E. Sacanella, R. Estruch, A. Urbano-Márquez.

Current Author Addresses: Drs. Fernández-Solà, Nicolás, Oriola, Sacanella, Estruch, and Urbano-Márquez: Alcohol Research and Cardiac Units, Department of Medicine, Hospital Clínic i Provincial, University of Barcelona, Villaroel, 170 08036, Barcelona, Spain.

Dr. Rubin: Department of Pathology and Cell Biology, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 279, Philadelphia, PA 19107-6799

Author Contributions: Conception and design: J. Fernández-Solà, J. María Nicolás, E. Rubin, A. Urbano-Márquez.

Analysis and interpretation of the data: J. Fernández-Solà, J. María Nicolás, E. Rubin.

Drafting of the article: J. Fernández-Solà, J. María Nicolás, E. Rubin, A. Urbano-Márquez.

Critical revision of the article for important intellectual content: E. Rubin

Final approval of the article: A. Urbano-Márquez.

Provision of study materials or patients: E. Sacanella, R. Estruch.

Statistical expertise: J. María Nicolás.

Obtaining of funding: J. Fernández-Solà, J. María Nicolás, R. Estruch, E. Rubin.

Administrative, technical, or logistic support: J. Oriola.

Collection and assembly of data: E. Sacanella.


Ann Intern Med. 2002;137(5_Part_1):321-326. doi:10.7326/0003-4819-137-5_Part_1-200209030-00007
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All participants were normotensive. Patients in both groups were of similar age and reported similar amounts of tobacco and alcohol consumption (Table 1). Clinical and laboratory results showed no differences between the groups other than those associated with cardiac dysfunction (Tables 1 and 2). Electrocardiographic results for the patients in group 1 showed atrial fibrillation in 6 patients, conduction defects in 4 patients, and premature ventricular contractions in 9 patients. In group II, 1 patient had atrial fibrillation, 2 had minor conduction defects, and 4 had premature ventricular contractions. The mean (±SE) LVEF was 33.6% ± 2.4% in group I and 64.9% ± 0.8% in group II. Group I had mean (±SE) values of 64.1 ± 2.2 mm for end-diastolic diameter, 50.2 ± 2.5 mm for end-systolic diameter, 305 ± 18 g for left ventricular mass, and 22.6% ± 1.4% for shortening fraction. We found no evidence of valvular disease or other structural cardiac abnormalities in any of these patients. In addition, results of the treadmill test showed no evidence of ischemic heart disease in any patient from group I.

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Summary for Patients

Genetic Variations and the Risk for Alcohol-Induced Weakness of the Heart

The summary below is from the full report titled “Angiotensin-Converting Enzyme Gene Polymorphism Is Associated with Vulnerability to Alcoholic Cardiomyopathy.” It is in the 3 September 2002 issue of Annals of Internal Medicine (volume 137, pages 321-326). The authors are J Fernández-Solà, JM Nicolás, J Oriola, E Sacanella, R Estruch, E Rubin, and A Urbano-Márquez.

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