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Acute Myocardial Infarction and Renal Dysfunction: A High-Risk Combination

R. Scott Wright, MD; Guy S. Reeder, MD; Charles A. Herzog, MD; Robert C. Albright, DO; Brent A. Williams, MS; David L. Dvorak, RN; Wayne L. Miller, MD; Joseph G. Murphy, MD; Stephen L. Kopecky, MD; and Allan S. Jaffe, MD
[+] Article and Author Information

From Mayo Clinic, Rochester, and University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, Minnesota.


Acknowledgment: The authors thank Amy Oeltjen for excellent administrative work.

Grant Support: By the Mayo Foundation and the Mayo Alliance for Clinical Trials.

Requests for Single Reprints: R. Scott Wright, MD, Division of Cardiology, Mayo Clinic, Mayo Alliance for Clinical Trials, Stabile 5, 150 Third Street SW, Rochester, MN 55902; e-mail, wright.scott@mayo.edu.

Potential Financial Conflicts of Interest:Consultancies: C.A. Herzog, A.S. Jaffe; Grants received: R.S. Wright, C.A. Herzog, A.S. Jaffe; Grants pending: A.S. Jaffe.

Current Author Addresses: Drs. Wright and Kopecky and Mr. Dvorak: Division of Cardiology, Mayo Alliance for Clinical Trials, Mayo Clinic, Stabile 5, 150 Third Street SW, Rochester, MN 55902.

Drs. Reeder, Miller, Murphy, and Jaffe: Division of Cardiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Dr. Herzog: Hennepin County Medical Hospital—Cardiology, 701 Park Avenue, Mail Station 865A, Minneapolis, MN 55415.

Dr. Albright: Division of Nephrology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905.

Mr. Williams: Division of Biostatistics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905.

Author Contributions: Conception and design: R.S. Wright, C.A. Herzog, S.L. Kopecky.

Analysis and interpretation of the data: R.S. Wright, G.S. Reeder, R.C. Albright, B.A. Williams, W.L. Miller, J.G. Murphy, S.L. Kopecky, A.S. Jaffe.

Drafting of the article: R.S. Wright, G.S. Reeder, R.C. Albright, W.L. Miller, J.G. Murphy, A.S. Jaffe.

Critical revision of the article for important intellectual content: R.S. Wright, G.S. Reeder, C.A. Herzog, R.C. Albright, W.L. Miller, J.G. Murphy, S.L. Kopecky, A.S. Jaffe.

Final approval of the article: R.S. Wright, G.S. Reeder, R.C. Albright, B.A. Williams, W.L. Miller, J.G. Murphy, S.L. Kopecky, A.S. Jaffe.

Provision of study materials or patients: D.L. Dvorak, S.L. Kopecky.

Statistical expertise: B.A. Williams, A.S. Jaffe.

Obtaining of funding: R.S. Wright, S.L. Kopecky.

Collection and assembly of data: B.A. Williams, D.L. Dvorak, A.S. Jaffe.


Ann Intern Med. 2002;137(7):563-570. doi:10.7326/0003-4819-137-7-200210010-00007
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From our coronary care unit database, we identified 3106 consecutive patients who had acute MI between 1988 and 2000. A trained nurse collected the data from the medical record. The study was approved by the Mayo Foundation Institutional Review Board. All patients gave informed consent as required by Minnesota law.

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Figures

Grahic Jump Location
Figure 1.
In-hospital mortality as a function of creatinine clearance (P< 0.001).

To convert mL/min to mL/s, multiply by 0.0167.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Postdischarge survival as a function of creatinine clearance (P< 0.001).

To convert mL/min to mL/s, multiply by 0.0167.

Grahic Jump Location

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Summary for Patients

The Influence of Kidney Disease on Outcomes of Patients with Heart Attack

The summary below is from the full report titled “Acute Myocardial Infarction and Renal Dysfunction: A High-Risk Combination.” It is in the 1 October 2002 issue of Annals of Internal Medicine (volume 137, pages 563-570). The authors are RS Wright, GS Reeder, CA Herzog, RC Albright, BA Williams, DL Dvorak, WL Miller, JG Murphy, SL Kopecky, and AS Jaffe.

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