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Can Statins Cause Chronic Low-Grade Myopathy?

Scott M. Grundy, MD, PhD
[+] Article, Author, and Disclosure Information

Current Author Address: Scott M. Grundy, MD, PhD, Center for Human Nutrition and the Departments of Clinical Nutrition and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3.206, Dallas, TX 75390-9052.

Potential Financial Conflicts of Interest:Honoraria (from Merck & Co.; Pfizer, Inc.; Bristol-Myers Squibb; and Bayer); Grants (from Merck & Co. and Pfizer, Inc.)

Ann Intern Med. 2002;137(7):617-618. doi:10.7326/0003-4819-137-7-200210010-00015
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Statins (hydroxymethyl glutaryl coenzyme A reductase inhibitors) are highly effective drugs for reducing serum cholesterol and low-density lipoprotein cholesterol levels. Clinical trials have shown that they also reduce risk for coronary heart disease events, coronary procedures, and stroke by about one third (1). Millions of people in the United States and worldwide are being treated with statins. In clinical trials and in clinical practice, statins have proved to be remarkably safe.


statins ; myopathy

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