The death of Dr. John Hunter, the noted 18th-century Scottish surgeon, is probably the earliest, best-documented, and most ironic illustration of emotion worsening a cardiovascular pathologic state. By all accounts, Hunter was notorious for impatience, defensive argument, and irrational outbursts—epitomizing what today might be called a hostile “type A” personality. In 1785, he began to experience angina pectoris, a syndrome his friend William Heberden had only recently described. Despite having autopsied one of Heberden's patients with angina, Hunter either never recognized or never admitted his own condition for what it was. He did recognize the relationship between emotional upset and his symptoms when he claimed, “My life is at the mercy of any rogue who chooses to provoke me” (88). This proved to be one of the most ironic statements in medical history, for on 16 October 1793, incensed at remarks criticizing him at a meeting of the board of governors of St. George's Hospital, he left the room, collapsed, and dropped dead. At autopsy, his body demonstrated severe coronary arteriosclerosis.