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Genetic Variation in the Renin–Angiotensin System and Abdominal Adiposity in Men: The Olivetti Prospective Heart Study

Pasquale Strazzullo, MD; Roberto Iacone; Licia Iacoviello, MD, PhD; Ornella Russo; Gianvincenzo Barba, MD; Paola Russo, BS; Andria D'Orazio; Antonio Barbato, MD; Francesco Paolo Cappuccio, MD, FRCP; Eduardo Farinaro, MD; and Alfonso Siani, MD
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From Federico II University of Naples Medical School, Naples, Consorzio Mario Negri Sud, Santa Maria Imbaro, and Institute of Food Sciences, CNR, Avellino, Italy; and St. Georges' Hospital Medical School, London, United Kingdom.

Acknowledgments: The authors thank Dr. A. Scottoni, Dr. U. Candura, and Ms. M. Bartolomei for organizing and coordinating the fieldwork and the workers of the Olivetti factories for their cooperation. They also thank Drs. E. Ragone, F. Stinga, and L. Russo for fieldwork; Dr. Antonella Venezia for laboratory support; and Mrs. Rosanna Scala and Grazia Fanara for editorial assistance.

Grant Support: By funds from MURST (Italian Ministry of University and of Scientific and Technological Research COFIN, 1998 and 2000).

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Pasquale Strazzullo, MD, Department of Clinical and Experimental Medicine, Federico II University of Naples, via S. Pansini 5, 80131 Naples, Italy; e-mail, strazzul@unina.it.

Current Author Addresses: Drs. Strazzullo, Barbato, and Farinaro; Mr. Iacone; and Ms. O. Russo: Department of Clinical and Experimental Medicine, Federico II University of Naples, via S. Pansini 5, 80131 Naples, Italy.

Dr. Iacoviello and Ms. D'Orazio: Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, via Nazionale, Santa Maria Imbaro, 66030 Lanciano (Chieti), Italy.

Drs. Barba and Siani and Ms. P. Russo: Institute of Food Sciences, CNR, via Roma 52A/C, 83100 Avellino, Italy.

Dr. Cappuccio: St. Georges' Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom.

Author Contributions: Conception and design: P. Strazzullo, R. Iacone, L. Iacoviello, F.P. Cappuccio, E. Farinaro, A. Siani.

Analysis and interpretation of the data: P. Strazzullo, R. Iacone, L. Iacoviello, O. Russo, G. Barba, P. Russo, F.P. Cappuccio.

Drafting of the article: P. Strazzullo, R. Iacone, O. Russo.

Critical revision of the article for important intellectual content: P. Strazzullo, L. Iacoviello, G. Barba, P. Russo, F.P. Cappuccio, E. Farinaro, A. Siani.

Final approval of the article: P. Strazzullo, L. Iacoviello, P. Russo, F.P. Cappuccio, E. Farinaro, A. Siani.

Provision of study materials or patients: P. Strazzullo, A. D'Orazio, A. Barbato.

Statistical expertise: G. Barba, F.P. Cappuccio, A. Siani.

Obtaining of funding: P. Strazzullo.

Administrative, technical, or logistic support: R. Iacone, L. Iacoviello, A. D'Orazio.

Collection and assembly of data: O. Russo, A. Barbato.

Ann Intern Med. 2003;138(1):17-23. doi:10.7326/0003-4819-138-1-200301070-00007
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Table 1 summarizes the main characteristics of the participants of the Olivetti Prospective Heart Study at the 1994–1995 examination. Nine hundred fifty-nine participants were tested for ACE, AGT, and AT2R1 polymorphism. For the ACE I/D polymorphism, 40% (n = 385) had the DD genotype, 45% (n = 431) had the ID genotype, and 15% (n = 143) had the II genotype. For the AGT polymorphism, 31% (n = 297) had the M235M genotype, 48% (n = 460) had the M235T genotype, and 21% (n = 202) had the T235T genotype. For the AT2R1 polymorphism, 54% (n = 518) had the A1166A genotype, 39% (n = 377) had the A1166C genotype, and 7% (n = 64) had the C1166C genotype. All three polymorphisms were in Hardy–Weinberg equilibrium, showing that the study sample excluded selection pressure for the genotypes under investigation.

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Grahic Jump Location
Age-adjusted time changes in body weight (leftrightDI/DDDnIDIInPP

) and diastolic blood pressure ( ) over 20 years of follow-up, according to the recessive model of the angiotensin-converting enzyme gene polymorphism. White bars indicate participants with the genotype ( = 129); shaded bars indicate participants with the or genotype ( = 185). For between-group difference in body weight, = 0.033; for between-group difference in diastolic blood pressure, = 0.029.

Grahic Jump Location




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Summary for Patients

Genes of the Renin–Angiotensin System and the Development of Obesity in Men

The summary below is from the full report titled “Genetic Variation in the Renin–Angiotensin System and Abdominal Adiposity in Men: The Olivetti Prospective Heart Study.” It is in the 7 January 2003 issue of Annals of Internal Medicine (volume 138, pages 17-23). The authors are P Strazzullo, R Iacone, L Iacoviello, O Russo, G Barba, P Russo, A D'Orazio, A Barbato, FP Cappuccio, E Farinaro, and A Siani.


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